• Journal of Acupuncture Research
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• 제25권1호
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• pp.73-87
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• 2008

Objectives : The purpose of this study was to observe the anti-oxidative effects of electroacupuncture at Pungyung($ST_{40}$) in rats. Methods : The author performed several experiments, including measurements of body weightrelative liver weightslevels of albumin, total bilirubin, LDL-cholesterol, LDH, GOT and GPT in serum levels of SOD, glutathione, catalase, NO and MDA in the liver and histological analysis of the liver. Results : 1. Liver index was decreased in the $ST_{40}-EA$ group compared with the holder group and the control group. 2. LDL-cholesterol was significantly decreased in the $ST_{40}-EA$ group compared with the group. 3. SOD activity was significantly increased in the $ST_{40}-EA$ group and $ST_{40}-NR$ group compared with the control group. Glutathione activity was significantly increased in the $ST_{40}-EA$ group compared with the control group, the holder group, and the Sham-EA group. Catalase activity was significantly increased in the $ST_{40}-EA$ group compared with the control group and the holder group. Conclusions : These results suggest that electroacupuncture at $ST_{40}$ has an antioxidant effect in rats.

• 동의생리병리학회지
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• 제28권6호
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• pp.601-606
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• 2014

The purpose of this study is to research the effects of acupuncturing BL40 and ST36 and to determine the mechanism of action of acupuncturing BL40 and ST36 by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. To determine the mechanism of action of acupuncturing BL40 and ST36, pretreatment with indomethacine and methylene blue was performed. Acupuncturing BL40 and ST36 significantly increased rCBF, and the increased rCBF by acupuncturing BL40 and ST36 was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Acupuncturing BL40 and ST36 decreased MABP, and decreased MABP by acupuncturing BL40 and ST36 was not changed by pretreatment with indomethacin and methylene blue. This result suggested that acupuncturing BL40 and ST36 might significantly increase rCBF by dilating arterial diameter and mechanism of acupuncturing BL40 and ST36 might be mediated by cyclooxygenase and guanylate cyclase.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2012년도 임시총회 및 하계학술연구발표회
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• pp.70-71
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• 2012

In summary, the BLS experiments was applied to investigate the magnetic properties of $Co_{40}Fe_{40}B_{20}$ thin films. We find that the exchange stiffness constant decrease with increasing Ar gas pressure.

• Journal of Animal Science and Technology
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• 제47권6호
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• pp.1001-1008
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• 2005

본 연구는 젖소에서 곡류의 가공형태 및 RUP수준이 효과를 구명하기 위하여 분만 전 3주부터 분만 후 3주까지 전환기 Holstein종 경산우 20두(4처리 5반복)에게 TMR 사료를 GCR30 (파쇄옥수수+RUP 30%), GCR40 (파쇄옥수수+RUP40%), FCR30 (후레이크옥수수+RUP 30%), FCR40 (후레이크옥수수+RUP 40%)로 하여, 건유기와 비유기로 구분하여 배합하여 급여하였다. 본 연구로부터 얻어진 결과를 요약하면 다음과 같다. 분만전 사료의 건물 섭취량은 처리별로 평균 14～15kg이었으며, 건유기간 중 사료섭취량에는 유의한 차이가 없었으나, 분만 후 건물섭취량에서는 RUP 40%에서 섭취량이 RUP30%보다 높게 나타났다 (P＜0.05). 유량은 RUP 40 % 사료를 급여한 구 (FCR40과 GCR40)에서 유의하게 높은 결과를 보여주었다. 유단백질과 유지방을 분석한 결과, 유지방에 있어서는 옥수수 가공 형태인 후레이크와 파쇄처리에 따른 유의있는 결과를 보여주지는 않았다. 혈액 내 대사물질은 분만 전에 비하여 분만 당일의 수치가 모든 처리에서 상승하는 것을 볼 수 있었으며, 분만전ㆍ후의 NEFA의 농도를 보면 모든 처리구에서 분만을 기점으로 상승하였으며, 특히 분만 후에 유량이 높았던 FCR40에서 NEFA 수준이 전반적으로 높은 경향을 보였다 (p<0.05). Glucose와 cortisol 수준은 포도당 농도에서 FCR40구의 건유기가 다른 구보다 유의하게 높았으나 타 처리구간에서는 유의차가 인정되지 않았다. Insulin 농도에 있어서도 분만 전에 처리 간에 유의한 차이가 없으나, 분만 후에는 타처리와 비교하여 FCR40 처리에서 유의하게 높은 농도를 보여 주었다 (p<0.05). 이 시험에서는 옥수수의 가공형태보다는 동량의 단백질에 RUP 함량을 30 %에서 40 %로 증가시킴으로서 에너지, 단백질 이용 효율을 높여 젖소의 생산성을 높일 수 있을 것으로 생각된다.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2019년도 전력전자학술대회
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• pp.177-179
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• 2019

본 논문은 리튬폴리머 배터리를 기반으로 한 40 kV 펄스전원장치의 설계를 다룬다. 기존에 설계된 펄스전원장치는 삼상 380 V AC 입력 전원을 통해 구동되었으나, 이를 배터리 기반 2 kW 용량의 고전압 충전기를 통해 구동하도록 설계한다. 이 고전압 충전기는 44 V 리튬 폴리머 배터리를 기반으로 2 kW의 출력 용량을 갖도록 삼상 델타-와이 변압기 구조의 LCC 공진형 컨버터로 제작된다. 이를 통해 설계된 펄스전원장치는 최대 전압 40 kV, 펄스 폭 1.5 us - 5 us, 최대 펄스 반복율 3 kHz의 사양을 갖는다. 본 논문을 통해 2 kW급 고전압 충전기의 설계 및 분석을 하고 시뮬레이션 결과, 실험 결과를 분석한다. 또한 배터리 기반 40 kV 펄스 전원 장치의 시스템을 설명하며, 저항부하 실험을 통해 안정적인 동작과 성능을 검증한다.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2005년도 종합학술발표회 논문집 Vol.15 No.1
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• pp.191-196
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• 2005

A low-cost, high-performance 40 Gb/s clock recovery module using a phase-locked loop(PLL) for a 40 Gb/s optical receiver has been designed and implemented. It consists of a clock recovery circuit, a RF mixer and frequency discriminator for phase/frequency detection, a DR-VCO, a phase shifter, and a hold circuit. The recovered 40 GHz clock is synchronized with a stable 10 GHz DR-VCO. The clock stability and jitter characteristics of the implemented PLL-based clock recovery module has shown to significantly improve the performance of the conventional open-loop type clock recovery module with DR filter. The measured peak-to-peak RMS jitter is about 230 fs. When input signal is dropped, the 40 GHz clock is generated continuously by hold circuit. The implemented clock recovery module can be used as a low-cost and high-performance receiver module for 40 Gb/s commercial optical network.

• 한국토양비료학회지
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• 제43권5호
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• pp.540-545
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• 2010

본 연구는 시설재배오이의 적정 관개시점의 평가를 통한 물 관리 방안을 설정하기 위하여 수행하였다. 경기도 연천군 전곡읍 소재의 오이 시설재배 농가에서 Tensiometer를 이용한 자동관개시스템을 구축하고, 이를 이용하여 관개시점이 15, 20, 30, 40 kPa인 4개의 처리구를 두어 일반농가의 관행 관개방법과 비교하여 오 이의 생산력과 물의 이용효율을 평가하였다. 관개방법에 따른 오이과실의 수량과 당도는 통계학적 차이는 없었으나 15 kPa보다 20, 30 kPa, 관행 처리구에서 각각 수량이 6%, 7%, 9% 높게 나타냈으며, 과실의 당도는 30 kPa 처리구에서 가장 높은 값인 4.1$^{\circ}brix$, 관행과 40 kPa에서 가장 낮은 값인 3.7 $^{\circ}brix$를 나타냈다. 건물중은 30 kPa에서 가장 큰 값을 나타내었으며 15, 20, 30 40 kPa처리구의 식물체 수분함량은 92, 86, 85, 84%로 조사되었다. 오이의 생육 기간 중 사용된 관개량은 관행 > 15 kPa > 20 kPa > 30 kPa > 40 kPa 순이었으며, 절수율은 관행을 기준으로 15 kPa 처리구에서 46%, 20 kPa 처리구에서 48%, 30 kPa 처리구에서 58%, 40 kPa 처리구에서 69%가 절약되었다. 1 kg의 과실을 생산하는데 사용되는 물이용률은 관행이 가장 비효율적이며, 관행에 비해 15, 20, 30, 40 kPa처리구가 관행구보다 36~67%정도 물이 적게 사용되었다. 과실수량과 당도 등에 처리별 유의한 차이가 없으므로 30~40 kPa수준으로 관개 시점 설정 시 60%이상의 물절약이 가능 할 것으로 판단된다.

• ETRI Journal
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• 제30권2호
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• pp.261-267
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• 2008

In this paper, we propose and demonstrate a cost-effective technique to upgrade the capacity of dense wavelength division multiplexing (DWDM) networks to a 40 Gb/s line rate using the existing 10 Gb/s-based infrastructure. To accommodate 40 Gb/s over the link optimized for 10 Gb/s, we propose applying a combination of super-FEC, carrier-suppressed return-to-zero, and pre-emphasis to the 40 Gb/s transponder. The transmission of 40 Gb/s DWDM channels over existing 10 Gb/s line-rate long-haul DWDM links, including $40{\times}40$ Gb/s transmission over KT's standard single-mode fiber optimized for 10 Gb/s achieves successful results. The proposed upgrading technique allows the Q-value margin for a 40 Gb/s line rate to be compatible with that of 10 Gb/s.

• Biomolecules & Therapeutics
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• 제26권6호
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• pp.599-607
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• 2018

Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in premature termination of its development. Here, we investigated whether TAK-875 directly inflicts toxicity on hepatocytes and explored its underlying mechanism of toxicity. TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration-(>$50{\mu}M$) and time-dependent manners, both of which corresponded with ROS generation. An antioxidant, N-acetylcysteine, attenuated TAK-875-mediated hepatotoxicity, which confirmed the role of ROS generation. Of note, knockdown of GPR40 using siRNA abolished the hepatotoxicity of TAK-875 and attenuated ROS generation. In contrast, TAK-875 induced no cytotoxicity in fibroblasts up to $500{\mu}M$. Supporting the hepatotoxic potential of TAK-875, exposure to TAK-875 resulted in increased mortality of zebrafish larvae at$25{\mu}M$. Histopathological examination of zebrafish exposed to TAK-875 revealed severe hepatotoxicity as manifested by degenerated hypertrophic hepatocytes with cytoplasmic vacuolation and acentric nuclei, confirming that TAK-875 may induce direct hepatotoxicity and that ROS generation may be involved in a GPR40-dependent manner.

• Fisheries and Aquatic Sciences
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• 제23권1호
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• pp.2.1-2.6
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• 2020

Background: As the cost of fishmeal continues to rise, there will be a need to optimize the diet by minimizing dietary fishmeal inclusion in aquafeed. In this study, a 7-week experiment was conducted to evaluate soybean meal, fermented soybean meal (soytide), and sesame meal as fishmeal replacers in whiteleg shrimp, Litopenaeus vannamei. Methods: A 30%-based fishmeal diet was considered as control (CON), six other diets were prepared by replacing 20% or 40% of fishmeal with soybean meal (SB₂₀ and SB₄₀), fermented soybean meal (ST₂₀ and ST₄₀), or sesame meal (SM₂₀ and SM₄₀) from the CON diet. Twenty shrimp with average initial weight of 0.65 ± 0.05 g (mean ± SD) were randomly distributed into 21 tanks (45 L) and fed four times a day. Water temperature was controlled at 28 ± 1 ℃ and aeration was provided by air stones. Results: Weight gain, specific growth rate, feed efficiency, and protein efficiency ratio of shrimp fed CON showed no significant differences compared to shrimp fed all the other diets. However, growth performance of shrimp fed ST₂₀ diet was significantly higher than those of shrimp fed the SM₂₀ and SM₄₀ diets (P < 0.05). Superoxide dismutase activity (SOD) of shrimp fed CON, ST₂₀, and ST₄₀ diets was significantly higher than those of shrimp fed the SB₄₀ and SM₄₀ diets. But there were no significant differences among shrimp fed CON, SB₂₀, ST₂₀, ST₄₀, and SM₂₀ diets. Also, lysozyme activity of shrimp fed ST₂₀ diet was significantly higher than those of shrimp fed the SB₄₀ and SM₄₀ diets. Although, lysozyme activity of shrimp fed the CON diet was not significantly different compared to shrimp fed all the other experimental diets. Conclusions: Therefore, SB, ST, and SM could replace 40% of fishmeal based on growth performance and lysozyme. According to the SOD activity, SB and SM could replace 20% of fishmeal and ST could replace 40% of fishmeal in juvenile whiteleg shrimp Litopenaeus vannamei.