• Title/Summary/Keyword: $^{211}At$

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211At and 211At-labeled radiopharmaceuticals for targeted alpha therapy

  • Kang, Choong Mo;Lee, Kyo Chul;Lee, Yong Jin
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.4 no.2
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    • pp.99-105
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    • 2018
  • $^{211}At$ is an alpha emitting radionuclide, which can be produced using cyclotron with alpha beam. In addition, its strong linear energy transfer and iodine-like chemistry make that $^{211}At$ is one of the most attractive radionuclide in the field of targeted alpha therapy. In this review, production, labeling, and radiopharmaceuticals of $^{211}At$ will be discussed.

Effect of dietary supplementation of Bacillus subtilis TLRI 211-1 on laying performance, egg quality and blood characteristics of Leghorn layers

  • Ming-Yang Tsai;Bor-Ling Shih;Ren-Bao Liaw;Wen-Tsen Chen;Tsung-Yu Lee;Hsi-Wen Hung;Kuo-Hsiang Hung;Yih-Fwu Lin
    • Animal Bioscience
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    • v.36 no.4
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    • pp.609-618
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    • 2023
  • Objective: TLRI 211-1 is a novel Bacillus subtilis strain. This experiment was to investigate dietary supplementation of TLRI 211-1 on laying performance, egg quality and blood characteristics of layers. Methods: One hundred and twenty 65-wk-old Leghorn layers were divided into four treatment groups for 8 weeks experiment. Each treatment had three replicates. The basal diet was formulated as control group with crude protein 17% and metabolizable energy 2,850 kcal/kg and supplemented with TLRI 211-1 0.1%, 0.3%, and commercial Bacillus amyloliquefaciens 0.1% as treatment 2, 3 and 4 groups, respectively. Both TLRI 211-1 and commercial Bacillus amyloliquefaciens were adjusted to contain 1×109 colony-forming unit (CFU)/mL (g), hence the 0.1% supplemental level was 1×109 CFU/kg. Results: The results showed that TLRI 211-1 0.3% and commercial B. amyloliquefaciens groups had higher weight gain than the other groups; TLRI 211-1 0.1% group had better feed to eggs conversion ratio than the control and commercial B. amyloliquefaciens groups (p<0.05). Bacillus subtilis supplementation increased yolk weight (p<0.05). In egg quality during storage, TLRI 211-1 0.1% had higher breaking strength than the control group at the second week of storage (p<0.05). At the third week of storage, TLRI 211-1 0.3% had higher Haugh unit (p<0.05). Hens fed diets supplemented with TLRI 211-1 0.3% significantly decreased blood triglyceride levels and increased blood calcium levels (p<0.05). TLRI 211-1 0.3% group had lower H2S (p<0.05) and hence had less unpleasant odor in excreta of hens. Conclusion: In conclusion, supplementation with 0.1% TLRI 211-1 can significantly improve feed to eggs conversion ratio. TLRI 211-1 supplementation also can maintain eggs at their optimum quality level during storage. The study showed that B. subtilis TLRI 211-1 can be used as feed additives for improving egg production performance and egg quality.

$Y_BaCuO_5$ Distribution within $YBa_2Cu_3O_{7-x}$ Grains of Melt Infiltration Processed YBCO Oxides (융융체 침투법으로 제조한 YBCO 산화물에서 $YBa_2Cu_3O_{7-x}$ 결정립 내 $Y_BaCuO_5$ 입자분포)

  • 김찬중;이동만;지영아;박해웅;홍계원
    • Journal of Powder Materials
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    • v.7 no.4
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    • pp.205-211
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    • 2000
  • Distribution of $Y_2BaCuO_5$ (211) Particles within $YBa_2Cu_3O_{7-x}/$ (123) grains of melt infiltration processed YBCO oxides was investigated. Processing parameters were a temperature, atmosphere (air and $O_2$) and initial 211 size. The 211 particles were distributed randomly within the 123 grains when the initial 211 size was large, while they made x-like pattern and/or butterfly-like patterns when the 211 size was small. The 211 patterns were more clearly observed in the samples prepared at higher temperatures and under $O_2$ atmosphere. The 211 distribution was explained in terms of the interfacial energy relationship among the solid, particle and melt.

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Method of simultaneous synthesize for Y123 and Y211 and fabrication of YBCO single crystal (Y123와 Y211분말의 동시 합성과 YBCO 초전도 단결정 제조)

  • 안재원;최희락;한영희;한상철;정년호;성태현
    • Proceedings of the International Microelectronics And Packaging Society Conference
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    • 2002.05a
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    • pp.224-233
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    • 2002
  • A common YBCO powder has been made from a mixture of Y123 and Y211 that heated at different temperatures, respectively. The synthesis temperature of Y211 is lower than Y123. If Y211 has been heated as a synthesis temperature of Y123, a particle size of it may be very coarse. It exist as one of main defects for superconductor. But We simultaneously synthesize a YBCO(its composition is (Y123+0.4Y211)+$lwt%CeO_2$) using polymeric complex method. In the YBCO, the Y123 is synthesized lower temperature than other methodes, and its crystal structure is orthorombic. For measurement of these superconducting properties, we fabricated a YBCO single crystal. The manufactured YBCO single crystal is measured a magnetic distribution device using 0.5Tesla magnet and trapped magnet fields in it are 0.2Tesla.

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CO Adsorption and Reaction on Clean and Zn-deposited Au(211) surface

  • Jo, Sang-Wan;Mbuga, F.;Ogasawara, H.;Nilsson, A.
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.128.2-128.2
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    • 2013
  • Crucially, effective catalysts must be capable of efficiently catalyzing the protonation of adsorbed CO to adsorbed CHO or COH. One of the strategies is alloying with metals with higher oxygen affinity and Au-Zn alloy is one of the best candidates. At first, we made Au-Zn alloy using vacuum evaporating method. Zn was deposited on the Au(211) surface and the amount was estimated by X-ray photoelectron spectroscopy (XPS) using the relative sensitivity of Au 4f and Zn 3d. We investigated CO adsorption on a clean Au(211) and Au-Zn alloy using temperature-programmed desorption (TPD) and XPS. From the TPD results, we can conclude that the presence of the particular step sites at the Au(211) surface imparts stronger CO bonding and Zn atoms are sitting on the step sites at the Au(211) when Zn is deposited. The XPS results show the oxygen atoms of CO bond Zn atoms on Au-Zn surface. It should be an evidence that alloying Zn atoms that has high oxygen affinity into an electrocatalyst may allow CHO* to bind to the surface through both the carbon and oxygen atoms.

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A Study on the Growth Behavior of $Y_2Ba_1Cu_1O_5$ Phase in Y-Ma-Cu-O System (Y-Ma-Cu-O계에서 $Y_2Ba_1Cu_1O_5$상의 성장거동에 관한연구)

  • Im, Dae-Ho;Song, Myeong-Yeop;Park, Jong-Hyeon;Lee, Hui-Gyun;Won, Dong-Yeon;Hong, Gye-Won
    • Korean Journal of Materials Research
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    • v.4 no.8
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    • pp.870-876
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    • 1994
  • In order to investigate the growth behavior of $Y_{2}Ba_{1}Cu_{1}O_{5}$(211) particles in $Y_{1}Ba_{2}Cu_{3}O_{7-\delta}$(123), 123 samples were quenched in air after heat treatment on polycrystal and single crystal MgO substrates at $1100^{\circ}C$ for various periods. 211 grains grew with the increase in holding time. The growth of 211 grains was faster on the polycrystal MgO substrate than on the single crystal MgO substrate. In the samples with the compositions of 211+xCuO($0.2\le X \le 0.8$), the growth rate of 211 grains increased with the increase in CuO content. In the sample with x=0.6 the largest 211 grains were observed. 211 grains in the $Y_{2}Ba_{1}Cu_{1.8}Sn_{0.1}O_{5+\delta}$ samples were distributed very finely and homogeneously. The retarding effect of $SnO_2$ addition on the growth of 211 grain appeared more pronounced in a CuO melt than in a $BaCuO_{2}$+ CuO melt.

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Milling Effects of $Y_2BaCuO_5$ Precursor Powder with $CeO_2$ Addition on the Critical Current Density of Liquid Infiltration Growth Processed $YBa_2Cu_3O_{7-y}$ Bulk Superconductors (액상 침투 성장법으로 제조된 $YBa_2Cu_3O_{7-y}$ 벌크 초전도체의 임계전류밀도에 대한 $CeO_2$ 첨가된 $Y_2BaCuO_5$ 분말의 밀링 효과)

  • Asif, Mahmood;Jun, Byung-Hyuk;Kim, Chan-Joong
    • Progress in Superconductivity
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    • v.12 no.1
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    • pp.6-11
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    • 2010
  • The milling effects of a precursor $Y_2BaCuO_5$ (Y211) powder having 1 wt.% $CeO_2$ on the microstructure and critical current density ($J_c$) of liquid infiltration growth (LIG) processed $YBa_2Cu_3O_{7-y}$ (Y-123) bulk superconductors were investigated. The microstructure analysis revealed that the Y211 size in the final Y-123 products decreased with increasing the milling time and a relatively high density and uniform distribution of Y211 inclusions were observed in the sample prepared using 8 h milled powder. However, the unexpected Y211 particles coarsening was observed from the 4 h milled sample which was further increased for 10 h milled sample. Critical current density ($J_c$) of the LIG processed Y-123 bulk superconductors was found to be dependent on the milling time of the Y211 precursor powder. The $J_c$ increased with the increase of milling time and reached up to a maximum at 8 h in the self field while 10 h milled sample showed lower $J_c$ at the same field which might be due to the exaggerated growth and non-uniform distribution of Y211 particles.

Adsorption of O Atom on Cr (100), (110), (111), and (211) Surfaces: An 5-Parameter Morse Potential Method Study

  • Han, Ling-Li;Liu, Tao
    • Bulletin of the Korean Chemical Society
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    • v.33 no.6
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    • pp.1867-1872
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    • 2012
  • The 5-parameter Morse potential (5-MP) method for the interaction between O atom and Cr surfaces is constructed in the present work. The adsorption of O on Cr (100), (110), (111), and (211) surfaces are studied with 5-MP in detail. The fourfold hollow site of the Cr (100) surface is favored for O atom. On Cr (110), quasithreefold site is favored with the parallel frequencies (the frequencies of O atom paralleling the metal surface) of 342 and 538 $cm^{-1}$, and perpendicular frequency (the frequency of O atom perpendicular to the metal surface) at 526 $cm^{-1}$. On Cr (111), the most favored mode for O atom is found to be the quasi-threefold site with the perpendicular frequency at 553 $cm^{-1}$ and the parallel frequencies at 253 and 399 $cm^{-1}$. According to our calculation results, we speculate the most preferred mode for O adsorption on Cr (211) surface is the quasithreefold site with the perpendicular frequency at 583 $cm^{-1}$ and the parallel frequencies at 449 and 185 $cm^{-1}$.

Resveratrol and clofarabine induces a preferential apoptosis-activating effect on malignant mesothelioma cells by Mcl-1 down-regulation and caspase-3 activation

  • Lee, Yoon-Jin;Lee, Yong-Jin;Lee, Sang-Han
    • BMB Reports
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    • v.48 no.3
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    • pp.166-171
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    • 2015
  • We previously demonstrated that resveratrol and clofarabine elicited a marked cytotoxicity on malignant mesothelioma (MM) MSTO-211H cells but not on the corresponding normal mesothelial MeT-5A cells. Little is known of the possible molecules that could be used to predict preferential chemosensitivity on MSTO-211H cells. Resveratrol and clofarabine induced downregulation of Mcl-1 protein level in MSTO-211H cells. Treatment of cells with cycloheximide in the presence of proteasome inhibitor MG132 suggested that Mcl-1 protein levels were regulated at the post-translational step. The siRNA-based knockdown of Mcl-1 in MSTO-211H cells triggered more growth-inhibiting and apoptosis-inducing effects with the resultant cleavages of procaspase-3 and its substrate PARP, increased caspase-3/7 activity, and increased percentage of apoptotic propensities. However, the majority of the observed changes were not shown in MeT-5A cells. Collectively, these studies indicate that the preferential activation of caspase cascade in malignant cells might have important applications as a therapeutic target for MM.

AMINO ACID DIGESTIBILITY TO PIGS IN VARIOUS FIBER SOURCES 2. TRUE DIGESTIBILITY OF AMINO ACIDS IN ILEAL DIGESTA AND FECES

  • Nongyao, A.;Han, In K.;Choi, Y.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.4 no.3
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    • pp.211-218
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    • 1991
  • The effects of dietary fiber on true digestibility of amino acids by growing pigs were studied, using semi-purified diets formulated from alfalfa meal, cassava leaf meal, rubber seed meal and leucacna meal at 20% level. A protein-free diet including 5% cellulose was formulated for correcting the endogenous amino acid loss. Across all the diets, arginine was the most digestible while the least at ileal level was threonine; methionine and/or histidine at fecal level respectively. The true digestibility value of amino acids at ileal level were higher than at fecal level except control diet (cellulose). The true digestibility values at ileal level were similar for all diets but differed at fecal level in different magnitude. These results indicate that undigestible compound in individual feedstuff might confound. True digestibility should be studied together for accurate diet formulation as apparent digestibility decreased when their amino acid concentration in the diet was reduced.