• 핵의학기술
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• 제16권2호
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• pp.106-109
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• 2012

최근 늘어나는 [$^{18}F$]FDG-PET 검사 증대와 더불어 새로운 방사성의약품으로 [$^{11}C$]아세테이트 검사가 신설되고 다양한 연구용 $^{11}C$-표지 방사성의약품 이용이 증대되고 있다. 본 연구에서는 성공리에 수행한 한국형 사이클로트론의 $^{11}C$-표적시스템을 이용하여, $[^{11}C]CO_2$ 생산 최적화 및 임상에서 사용가능한 $^{11}C$-표지 방사성의약품 생산 적용 연구를 수행하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1699-1704
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• 2005

In this research the energy degrader, which is the most fragile part of the security of a target, has been newly designed to improve the performance of the gas target. Also, the numerical analysis of the heat movement and mechanical movement during the operation of the target has been accomplished. The heat analysis and structure analysis which are using the cooling water flow and pressure in the energy degrader and the Nastran mediocrity finite element analysis program, has been considered with the heat movement and mechanical movement according to the current capacity of proton beam which determines the production yield of the radioactive isotope. Also the possible use range has been determined, and at the same time the most suitable running condition according to the current capacity of proton beam has been suggested.

• 한국공작기계학회논문집
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• 제15권3호
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• pp.24-31
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• 2006

The energy degrader is the most fragile part of the security of a target, has been newly designed to improve the performance of the gas target. Also, the numerical analysis of the heat movement and mechanical movement during the operation of the target has been accomplished. The heat analysis and structure analysis which are using the cooling water flow and pressure in the energy degrader and the finite element analysis program, has been considered with the heat movement and mechanical movement according to the current capacity of proton beam which determines the production yield of the radioactive isotope. Also the possible use range has been determined and at the same time the most suitable running condition according to the current capacity of proton beam has been suggested.

• 핵의학기술
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• 제15권1호
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• pp.86-89
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• 2011

최근 들어 양전자방출단층촬영(positron emission tomography, PET) 대표적인 진단검사인 FDG (2-[$^{18}F$]fluoro-2-deoxy-D-glucose)를 이용한 전신암 및 장기별 대사 검사뿐만 아니라 또 다른 양전자 방출 동위원소 탄소-11로 표지 된 다양한 방사성의약품 사용이 증가될 예정이다. 본 논문에서는 현재 국내에 설치 보급되어있는 국산 KOTRON-13 사이클로트론에 냉각 성능이 개선된 탄소-11 표적 장치를 설계, 제작하고, 다양한 생산시험을 통하여 탄소-11의 생산량 증대를 입증 하였다. 성공적으로 기존의 불소-18 타겟과 새로운 탄소-11 타겟 호환장치를 도입하였고, 실험 결과 고효율 탄소-11표적 장치가 내수성이 우수하고, 30분 조사 시 최대 2,000 mCi를 생산하였다. 본 시험결과를 통해 향후 불소-18만이 생산 가능했던 국산 KOTRON-13 사이클로트론에 효율적이고 안정적으로 탄소-11생산 시스템을 도입할 수 있음을 증빙하였다.

• 대한전자공학회논문지
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• 제25권3호
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• pp.276-286
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• 1988

In this paper, HLML-C (High Level Microprogramming Language C) is proposed, which is independent of target machines and has similar strucrure to C language. The HLML-C operations are defined for a abstract machine which contains characteristics of various microarchitectures, and can extend to define a target machine's special operations for efficient microcode generation. A microprogram written in this language is translated into a machine independent intermediate language on abstract machine with the information of a target machine's resource usage and then microoperations of a target machine. The HLML-C compiler is implemented with yacc and C language on VAX-11/750 (4.3 BSD) computer. Through the various test microprogram applied to HLML-C compiler, their results are analyzed.

• 한국발생생물학회지:발생과생식
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• 제28권2호
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• pp.37-45
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• 2024

This study aimed to elucidate the potential of Homeobox A11 (HOXA11) as a therapeutic target and a diagnostic methylation marker for cervical cancer. Gene expression analysis using cDNA microarray in cervical cancer cell lines revealed significantly reduced expression of the HOXA11 gene. Subsequent investigation of HOXA11 promoter methylation in samples from normal individuals and invasive cervical cancer patients showed over 53.2% higher methylation in cancer scrapes compared to normal scrapes. Furthermore, overexpression of HOXA11, which is downregulated in cervical cancer, strongly suppressed cell growth in cervical cancer cell lines, HeLa and HT3. Additionally, we performed transferase dUTP nick end labeling assay and confirmed that the inhibition of cervical cancer cell proliferation occurred via apoptosis. Mechanistically, overexpression of HOXA11 led to mitochondrial apoptosis characterized by PARP cleavage due to increased c-Myc and enhanced cytochrome C secretion into the cytoplasm. These findings suggest that HOXA11 could potentially serve as a methylation marker for diagnosing cervical cancer and as a novel therapeutic target for its treatment.

• 한국인터넷방송통신학회논문지
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• 제21권5호
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• pp.11-18
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• 2021

소형 Radio Frequency 추적레이다는 표적에 대하여 전천후 Radio Frequency 신호 처리를 통하여 표적을 식별하고 주요 표적에 대하여 표적을 탐색, 탐지하여 추적하는 Radio Frequency 센서를 보유한 추적시스템이다. 본 논문에서는 전천후 Radio Frequency를 이용하여 표적 정보를 획득하여 실시간 신호처리를 통하여 표적을 식별하기 위한 고속의 멀티코어 DSP인 TMS320C6678과 XILINX FPGA(Field Programmable Gate Array)가 탑재된 보드 개발의 내용을 설명한다. DSP, FPGA 선정과 신호처리를 위한 DSP-FPGA 결합 아키텍처에 대하여 제안하고 또한 고속의 데이터 전송을 위한 SRIO의 설계에 대하여 설명한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.651-654
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• 1988

This paper proposes a microcode generating system which automatically generates the microcode of various target machine by inputing the intermediate language (MDIL) from the machine independent HLML-C (High Level Microprograming Language C) language. The MOP's (Microoperations) which is modeled 7-tuples generate to extend MDIL by table driven method with the information of translation table for each target machine. As compaction being considered and the hardware resource of target machine used, the conflicts of hardware elements are removed possibly. This proposed system is implemented with C language and yacc on VAX-11/750 (UNIX 4.3 BSD).

• Journal of the Korean Physical Society
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• 제73권9호
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• pp.1255-1262
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• 2018

In this paper, alternative potentials to explain the scattering cross sections of $^{7,9,10,11,12,14}Be$ isotopes by a $^{12}C$ target nucleus at different energies are researched. For this purpose, fourteen different proximity potentials, such as Proximity 1966, Proximity 1976, Proximity 1977, Proximity 1979, Proximity 1984, Proximity 1988, Proximity 1995, Broglia and Winther 1991, Aage Winther, Bass 1973, Bass 1977, Bass 1980, Christensen and Winther 1976, and $Ng{\hat{o}}$ 1980, are used to produce the real potential within the optical model. The imaginary potential is formed by using the Woods-Saxon potential. The theoretical results are compared with both experimental data and data reported in the literature. The results are in good agreement with the data. The proximity potentials are observed to play a significant role in obtaining the scattering cross sections of $^{7,9,10,11,12,14}Be$ isotopes.

• 한국해양공학회지
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• 제11권3호
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• pp.163-169
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• 1997

The simulation of target-scattered echo with the moving sonar platform and target in 3-dimensional ocean environment is essential to validate and evaluate the performance of a sonar system. This paper presents the improved target signal simulation on the basis of the highlight(HL) model and its realtime algorithm. In order to simulate the scattering highlight, the highlight is represented as a directional scatterer. The realtime generation algorithm of the target signal is realized by use of DSP chip, TMS320C40, where the 40 channels are equally separated to form a parallel processing task in 4 processors. The presented realtime-version of target signal simulation can be used as a target signal simulator in the development of ACM(Acoustic Counter Measure) and advanced sonar signal processing techniques.