The purpose of this study is to observe the effect of Woogyuyem on serum reaction and hepatic tissue in Cyclosporin A treated rats. In this study, the experimental rats divided two group(Control group and Sample group). Under the same condition, both control group and sample group were injected to abdomen with Cyclosporin A for 7days. And then, control group were administered water, sample group were administered Woogy-uyeum for 300days. The change of transaminase and bile acid and SOD activity in blood serum, hepatic tissue were measured at 3rd, 7th, 15th, 30th day. The obtained results are summarised as follows : 1. In the change of SGOT contents, as compared with control group, sample group was significantly decreased at 7th and 15th day. 2. In the. change of SGPT contents, as compared with control group, sample group was significantly decreased at 15th day. 3. In the change of serum bile acid contents, as compared with control group, sample group was significantly decreased at 7th and 15th day. 4. In the change of serum SOD activity, as compared with control group, sample group was significantly increased at 15th and 30th day. 5. In the change of hepatic tissue, as compared with control group, the vacuolation of hepatocytes in the sample group was reduced, the liver plates were reconstructed, and the epitheriai cell wasn't destructed.

In order to study the effects of Gualouzhishiltang and Gualouzhishiltangiiawei on hyperlipidemia white rats were ind uced by lipid metabolism disorder by the oral-administration of cholesterol. The effects of gualouzhishitang and gualouzhishiltangjiawei on lipid in serum were measured by the quantity of total-chohestarol and of H.D.L-cholesterol and of triglyceride and of phospholipid and of ${\beta}$-lipoprotein in serum The obtaind results are summarized as follow 1. The level of serum total-cholesterol, H.D.L-cholesterol, triglyceride, phospholipld, ${\beta}$-lipoprotem decresed in the S1-group and S2-group 2. The level of serum total-cholesterol and phospholipid showed significant value on 3,4 week of S1-group and S2-group. 3. The level of serum H.D.L-cholesterol showed significant value on 3,4 week of S1-group and on 4 week of S2-group. 4. The level of serum triglyceride showed significant value on 4 week of S1-group 5. The level of serum ${\beta}$-lipoprotein showed significant value on 4 week of S1 and S2-group. According to the above experimental results eualouzhishilta ng and Gualouzhishiltangjiawei are aseumed to have a curative effect against hyperlipidemia thus hyperlipidemia and phlegrnretention have relation each other.

In humans, an immediate allergic response to an allergen snay appear as either bronchial asthma unaccompanied by anaphylaxis or a severe bronchial constriction and spasm accompanied by anaphylaxis. Much experimental evidence with isolated asthmatic tissues has shown that histamine is released during the allergic reaction. Paradoxically, antihistamine treatment is ineffective in reversing bronchial asthma or anapllylaxis in a man. The present study objective is to search for protective agents(In-Sam-Yun-Pai-San-Ga-Gam-Bang) against bronchial constriction in treating a anaphylaxis. The result from this study is as follows. A single dose of In-Sam-Yun-Pai-San-Ga-Gam-Bang extract(3ml/kg body weight) 2 hrs prior to histamine-induced bronchial constriction test demonstrated significant protection. Based on the above result, It is considered that In-Sam-Yun-Pai-San-Ga-Gam-Bang can be used in bronchial asthma.

This study was performed to identify the effect of Backchulsan and Backpeundu, on the muco-substances of the goblet cells in the small and large intestines of the mouse. After injected castor oil into oral cavity, the experimental animals were administrated with 5.952mg per 30g body weight of Backchulsan, with 0.519mg per 30g body weight of Backpeundu. The specimens used in this study were obtained from the small and large intestines of the mouse. All specimens were stained with periodic acid-Schiff reaction, alcian blue pH 2.5 and alcian blue pH 1.0 procedures. The results were as follows : 1. The most remarkable decrease of neutral and acid mucosubstance was observed in the control group 1 and 6 hours after castor oil administration. 2. Increase of neutral and mucosubstance was observed in Backchulsan administration group 3 hours in comparision with that of control group administrated of castor oil, especially of the upper and lower villi regions. 3. Increase of neutral and acid mucosubstance was observed in Backpeundu administration group 6 hours in comparision with that of control group administration of castor oil. 4. The most remarkable increase of neutral and acid mucosubstance was observed in Backchulsan administration group after 3 hours in comparision with that of Backpeundu administration group.