대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
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소자도담강기탕(蘇子導痰降氣湯)의 호흡기 염증 완화효과

Relieving effect for respiratory inflammation of Sojadodamgangki-tang

  • 한윤지 (상지대학교 한의과대학 병리학교실 ) ;
  • 선창우 (상지대학교 한의과대학 침구의학교실 ) ;
  • 우연주 (상지대학교 한의과대학 생리학교실 ) ;
  • 이동혁 (상지대학교 한의학연구소) ;
  • 서진우 (상지대학교 한의과대학 한방신경정신의학교실 ) ;
  • 유준상 (상지대학교 한의학연구소) ;
  • 김주희 (상지대학교 한의학연구소) ;
  • 권보인 (상지대학교 한의학연구소)
  • Younji Han (Department of Pathology, College of Korean Medicine, Sangji University) ;
  • Changwoo Seon (Department of Acupuncture & Moxibustion, College of Korean Medicine, Sangji University) ;
  • Yeonju Woo (Department of Physiology, College of Korean Medicine, Sangji University) ;
  • Dong Hyuk Lee (Research Institute of Korean Medicine, Sangji University) ;
  • Jin-woo Suh (Department of Korean neuropsychiatry, College of Korean Medicine, Sangji University) ;
  • Jun-Sang Yu (Department of Sasang Constitutional Medicine, College of Korean Medicine, Sangji University) ;
  • Joo-Hee Kim (Department of Acupuncture & Moxibustion, College of Korean Medicine, Sangji University) ;
  • Bo-In Kwon (Department of Pathology, College of Korean Medicine, Sangji University)
  • 투고 : 2023.07.25
  • 심사 : 2023.08.20
  • 발행 : 2023.08.31
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초록

Objectives : Sojadodamgangki-tang and its main components are traditional korean medicinal methods for treatment of cough, sputum and dyspnea. Using a respiratory inflammatory model, we intend to reveal the anti-inflammatory effect and its immune mechanism of Sojadodamgangki-tang. Methods : We used a papain-induced respiratory inflammatory mouse model. 8-week-old female BALB/C mice were divided into 3 groups as follows: the following groups: saline control group, papain treated group (vehicle), papain and Sojadodamgangki-tang(200 mg/kg) treated group (n=4). To evaluate the anti-inflammatory effect of Sojadodamgangki-tang extracts, inflammatory cell infiltration was measured in bronchoalveolar lavage fluid (BALF) and nasal lavage fluid (NALF). In addition, the effects of Sojadodamgangki-tang extracts on Th2 cell population in lung were determined by using flow cytometry. Results : Sojadodamgangki-tang extracts administration reduced inflammatory cell infiltration in BALF and NALF, especially of eosinophils. Furthermore, total immunogloblin (Ig)-E levels was reduced in BALF and serum by drug administration. Interestingly, Sojadodamgangki-tang extracts treatment also decreased the Th2 cell (CD4+GATA3+) population in lung. Conclusions : Our findings indicate Sojadodamgangki-tang extracts have anti-inflammatory effects by mediating Th2 cell and B cell activation.

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과제정보

본 결과물은 2023년도 교육부의 재원으로 한국연구재단의 지원을 받아 수행된 지자체-대학 협력 기반 지역혁신 사업의 결과입니다(2022RIS-005).

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