Acknowledgement
The authors thank the families, patients, and control volunteers who participated in this research. The author thanks Mr. MJP for English editing support.
References
- Warr A, Robert C, Hume D, Archibald A, Deeb N, Watson M: Exome Sequencing: Current and Future Perspectives. G3 (Bethesda) 2015, 5(8):1543-1550. https://doi.org/10.1534/g3.115.018564
- Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL et al: Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med 2011, 13(3):255-262. https://doi.org/10.1097/GIM.0b013e3182088158
- Wang X, Wang H, Cao M, Li Z, Chen X, Patenia C, Gore A, Abboud EB, Al-Rajhi AA, Lewis RA et al : Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis. Hum Mutat 2011, 32(12):1450-1459. https://doi.org/10.1002/humu.21587
- Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C et al: Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging 2014, 35(10):2422 e2413-2426.
- Byun M, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, Boisson B, Picard C, Dewell S, Zhao C et al: Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. J Exp Med 2010, 207(11):2307-2312. https://doi.org/10.1084/jem.20101597
- Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, Shi JY, Zhu YM, Tang L, Zhang XW et al: Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011, 43(4):309-315. https://doi.org/10.1038/ng.788
- Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M et al: GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood 2012, 120(2):395-403. https://doi.org/10.1182/blood-2012-01-403220
- Snape K, Ruark E, Tarpey P, Renwick A, Turnbull C, Seal S, Murray A, Hanks S, Douglas J, Stratton MR et al: Predisposition gene identification in common cancers by exome sequencing: insights from familial breast cancer. Breast Cancer Res Treat 2012, 134(1):429-433. https://doi.org/10.1007/s10549-012-2057-x
- Cai J, Li L, Ye L, Jiang X, Shen L, Gao Z, Fang W, Huang F, Su T, Zhou Y et al: Exome sequencing reveals mutant genes with low penetrance involved in MEN2A-associated tumorigenesis. Endocr Relat Cancer 2015, 22(1):23-33. https://doi.org/10.1530/ERC-14-0225
- Chakraborty R, Savani BN, Litzow M, Mohty M, Hashmi S: A perspective on complementary/alternative medicine use among survivors of hematopoietic stem cell transplant: Benefits and uncertainties. Cancer 2015, 121(14):2303-2313. https://doi.org/10.1002/cncr.29382
- Efferth T, Li PC, Konkimalla VS, Kaina B: From traditional Chinese medicine to rational cancer therapy. Trends Mol Med 2007, 13(8):353-361. https://doi.org/10.1016/j.molmed.2007.07.001
- Kim JH, Shin YC, Ko SG: Integrating traditional medicine into modern inflammatory diseases care: multitargeting by Rhus verniciflua Stokes. Mediators Inflamm 2014, 2014:154561.
- Kim K-S KS-H, Eo W-K, Cheon S-H, Eom S-K, Jo H-J: Clinical research methodology for Traditional Korean Medicine treatment of lung cancer: Evidence-based approach. Journal of Korean Medical Classics 2010, 23(4):39-62.
- Park B-k LJ-h, Cho C-k, Shin H-k, Eom S-k, Yoo H-s. : Systemic review of clinical studies about Oriental medical treatment of cancer in Korea. Korean Journal of Oriental Internal Medicine 2008, 29(4):1061-1074.
- Swarup AB, Barrett W, Jazieh AR: The use of complementary and alternative medicine by cancer patients undergoing radiation therapy. Am J Clin Oncol 2006, 29(5):468-473. https://doi.org/10.1097/01.coc.0000221326.64636.b2
- Hunt KJ, Coelho HF, Wider B, Perry R, Hung SK, Terry R, Ernst E: Complementary and alternative medicine use in England: results from a national survey. Int J Clin Pract 2010, 64(11):1496-1502. https://doi.org/10.1111/j.1742-1241.2010.02484.x
- Adler SR, Fosket JR: Disclosing complementary and alternative medicine use in the medical encounter: a qualitative study in women with breast cancer. J Fam Pract 1999, 48(6):453-458.
- Gansler T, Kaw C, Crammer C, Smith T: A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society's studies of cancer survivors. Cancer 2008, 113(5):1048-1057. https://doi.org/10.1002/cncr.23659
- Chen LL, Lin JS, Lin JD, Chang CH, Kuo HW, Liang WM, Su YC: BCQ+: a body constitution questionnaire to assess Yang-Xu. Part II: Evaluation of reliability and validity. Forsch Komplementmed 2009, 16(1):20-27. https://doi.org/10.1159/000197770
- Lin JD, Chen LL, Lin JS, Chang CH, Huang YC, Su YC: BCQ-: a body constitution questionnaire to assess Yin-Xu. Part I: establishment of a provisional version through a Delphi process. Forsch Komplementmed 2012, 19(5):234-241. https://doi.org/10.1159/000343580
- Lin JS, Chen LL, Lin JD, Chang CH, Huang CH, Mayer PK, Su YC: BCQ-: A Body Constitution Questionnaire to assess Yin-Xu. Part II: evaluation of reliability and validity. Forsch Komplementmed 2012, 19(6):285-292. https://doi.org/10.1159/000346060
- Su YC, Chen LL, Lin JD, Lin JS, Huang YC, Lai JS: BCQ+: a body constitution questionnaire to assess Yang-Xu. Part I: establishment of a first final version through a Delphi process. Forsch Komplementmed 2008, 15(6):327-334. https://doi.org/10.1159/000175938
- Chen Z, Wang P: Clinical Distribution and Molecular Basis of Traditional Chinese Medicine ZHENG in Cancer. Evid Based Complement Alternat Med 2012, 2012:783923.
- Dai J, Fang J, Sun S, Chen Q, Cao H, Zheng N, Zhang Y, Lu A: ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine. Evid Based Complement Alternat Med 2013, 2013:235969.
- Berle CA, Cobbin D, Smith N, Zaslawski C: A novel approach to evaluate Traditional Chinese Medicine treatment outcomes using pattern identification. J Altern Complement Med 2010, 16(4):357-367. https://doi.org/10.1089/acm.2009.0367
- Jiang M, Zhang C, Zheng G, Guo H, Li L, Yang J, Lu C, Jia W, Lu A: Traditional chinese medicine zheng in the era of evidence-based medicine: a literature analysis. Evid Based Complement Alternat Med 2012, 2012:409568.
- Shi X, Tian L, Zhu XD, Wang HM, Qin H: Effect of Chinese drugs combining with chemotherapy on quality of life in 146 children with solid tumor. Chin J Integr Med 2011, 17(1):31-34. https://doi.org/10.1007/s11655-011-0608-3
- Hong J, Xiangwei W, Yanping C, Qionghui L, Wen L: An analysis of the long-term therapeutic effect of the integrated therapy of traditional Chinese medicine and radiotherapy on abdominal malignant tumor. J Tradit Chin Med 2005, 25(2):125-128.