DOI QR코드

DOI QR Code

Nano Yttrium-90 and Rhenium-188 production through medium medical cyclotron and research reactor for therapeutic usages: A Simulation study

  • 투고 : 2022.12.25
  • 심사 : 2023.02.08
  • 발행 : 2023.05.25

초록

The main goal of the coordinated project development of therapeutic radiopharmaceuticals of Y-90 and Re-188 is to exploit advancements in radionuclide production technology. Here, direct and indirect production methods with medium reactor and cyclotron are compared to evaluate derived neutron flux and production yield. First, nano-sized 186W and 89Y specimens are suspended in water in a quartz vial by FLUKA simulation. Then, the solution is irradiated for 4 days under 9E+14 n/cm2/s neutron flux of reactor. Also, a neutron activator including three layers-lead moderator, graphite reflector, and polyethylene absorbent- is simulated and tungsten target is irradiated by 60 MeV protons of cyclotron to generate induced neutrons for 188W and 90Sr production via neutron capture. As the neutron energy reduced, the flux gradually increased towards epithermal range to satisfy (n/2n,γ) reactions. The obtained specific activities at saturation were higher than the reported experimental values because the accumulated epithermal flux and nano-sized specimens influence the outcomes. The beta emitters, which are widely utilized in brachytherapy, appeal an alternative route to locally achieve a rational yield. Therefore, the proposed method via neutron activator may ascertain these broad requirements.

키워드

참고문헌

  1. A. Khorshidi, B. Khosrowpour, S.H. Hosseini, Determination of defect depth in industrial radiography imaging using MCNP code and SuperMC software, Nuclear Engineering and Technology 52 (7) (2020) 1597-1601, https://doi.org/10.1016/j.net.2019.12.010. 
  2. A. Khorshidi, Accelerator driven neutron source design via beryllium target and 208Pb moderator for boron neutron capture therapy in alternative treatment strategy by Monte Carlo method, Journal of Cancer Research and Therapeutics 13 (3) (2017) 456-465, https://doi.org/10.4103/0973-1482.179180. 
  3. A. Khorshidi, Neutron activator design for 99Mo production yield estimation via lead and water moderators in transmutation's analysis, Instruments and Experimental Techniques 61 (2) (2018) 198-204, https://doi.org/10.1134/s002044121802015x. 
  4. M. Jamre, M. Shamsaei, M.G. Maragheh, S. Sadjadi, Novel 175Yb-poly (L-Lactic acid) microspheres for transarterial radioembolization of unrespectable hepatocellular carcinoma, Iran J Pharm Res 18 (2) (2019) 569-578, https://doi.org/10.22037/ijpr.2019.1100668. 
  5. A. Khorshidi, Gold nanoparticles production using reactor and cyclotron based methods in assessment of 196,198Au production yields by 197Au neutron absorption for therapeutic purposes, Materials Science and Engineering C 68 (2016) 449-454, https://doi.org/10.1016/j.msec.2016.06.018. 
  6. A. Khorshidi, M. Ahmadinejad, S.H. Hosseini, Evaluation of a proposed biodegradable 188Re source for brachytherapy application: a review of dosimetric parameters, Medicine 94 (28) (2015), e1098, https://doi.org/10.1097/md.0000000000001098. 
  7. A. Khorshidi, Accelerator-based methods in radio-material 99Mo/99mTc production alternatives by Monte Carlo method: the scientific-expedient considerations in nuclear medicine, Journal of Multiscale Modelling 11 (1) (2020), 1930001, https://doi.org/10.1142/S1756973719300016. 
  8. F. Razghandi, R. Izadi, A. Mowlavi, Calculation of the dose of samarium-153-ethylene diamine tetramethylene phosphonate (153Sm-edtmp) as a radiopharmaceutical for pain relief of bone metastasis, Iranian Journal of Medical Physics 12 (4) (2015) 278-283, https://doi.org/10.22038/ijmp.2016.6843. 
  9. A. Khorshidi, Molybdenum-99 production via lead and bismuth moderators and milli-structure-98Mo samples by the indirect production technique using the Monte Carlo method, Physics Uspekhi 62 (9) (2019) 931-940, https://doi.org/10.3367/UFNr.2018.09.038441. 
  10. A. Khorshidi, A. Pazirandeh, Molybdenum transmutation via 98Mo samples using bismuth/lead neutron moderators, Europhysics Letters 123 (1) (2018), 12001, https://doi.org/10.1209/0295-5075/123/12001. 
  11. A. Khorshidi, Radiochemical parameters of molybdenum-99 transmutation in cyclotron-based production method using a neutron activator design for nuclear-medicine aims, Eur Phys J Plus 134 (2019) 249, https://doi.org/10.1140/epjp/i2019-12568-3. 
  12. A. Rabiei, M. Shamsaei, H. Yousefnia, S. Zolghadri, A.R. Jalilian, R. Enayati, Development and biological evaluation of 90Y-BPAMD as a novel bone seeking therapeutic Agent, Radiochimica Acta 104 (10) (2016) 727-734, https://doi.org/10.1515/ract-2015-2561. 
  13. A. Dasha, FF (Russ) Knapp Jr., An overview of radioisotope separation technologies for development of 188W/188Re radionuclide generators providing 188Re to meet future research and clinical demands, RSC Adv 5 (2015) 39012-39036, https://doi.org/10.1039/C5RA03890A. 
  14. K.V. Vimalnath, S. Chakraborty, A. Rajeswari, H.D. Sarma, J. Nuwad, U. Pandey, K. Kamaleshwaran, A. Shinto, A. Dash, Radiochemistry, pre-clinical studies and first clinical investigation of 90Y-labeled hydroxyapatite (HA) particles prepared utilizing 90Y produced by (n,g) route, Nuclear Medicine and Biology 42 (5) (2015) 455-464, https://doi.org/10.1016/j.nucmedbio.2015.01.006. 
  15. A. Khorshidi, Assessment of SPECT images using UHRFB and other low-energy collimators in brain study by Hoffman phantom and manufactured defects, Eur. Phys. J. Plus 135 (2020) 261, https://doi.org/10.1140/epjp/s13360-020-00238-6. 
  16. A. Asgari, M. Ashoor, L. Sarkhosh, A. Khorshidi, P. Shokrani, Determination of gamma camera's calibration factors for quantitation of diagnostic radionuclides in simultaneous scattering and attenuation correction, Current Radiopharmaceuticals 12 (1) (2019) 29-39, https://doi.org/10.2174/1874471011666180914095222. 
  17. J.S. Nabipour, A. Khorshidi, Spectroscopy and optimizing semiconductor detector data under X and g photons using image processing technique, Journal of Medical Imaging and Radiation Sciences 49 (2) (2018) 194-200, https://doi.org/10.1016/j.jmir.2018.01.004. 
  18. A. Khorshidi, M. Ashoor, S.H. Hosseini, A. Rajaee, Estimation of fan beam and parallel beam parameters in a wire mesh design, Journal of Nuclear Medicine Technology 40 (1) (2012) 37-43, https://doi.org/10.2967/JNMT.111.089904. 
  19. A. Takahashi, K. Himuro, S. Baba, Y. Yamashita, M. Sasaki, Comparison of TOFPET and bremsstrahlung SPECT images of yttrium-90: a Monte Carlo simulation study, Asia Ocean J Nucl Med Biol 6 (1) (2018) 24-31, https://doi.org/10.22038/aojnmb.2017.9673. 
  20. M. Ashoor, A. Khorshidi, Evaluation of crystals' morphology on detection efficiency using modern classification criterion and Monte Carlo method in nuclear, Proceedings of the National Academy of Sciences India Section A - Physical Sciences 89 (3) (2019) 579-585, https://doi.org/10.1007/s40010-018-0482-x. 
  21. B. Ponsard, Production of radioisotopes in the BR2 high-flux reactor for applications in nuclear medicine and industry, Journal of Labelled Compounds and Radiopharmaceuticals 50 (5-6) (2007) 333-337, https://doi.org/10.1002/jlcr.1377. 
  22. H. Poorbaygi, S.M. Aghamiri, S. Sheibani, A. Kamali-asl, E. Mohagheghpoor, Production of glass microspheres comprising 90Y and 177Lu for treating of hepatic tumors with SPECT imaging capabilities, Applied Radiation and Isotopes 69 (10) (2011) 1407-1414, https://doi.org/10.1016/j.apradiso.2011.05.026. 
  23. A.R. Jalilian, D. Beiki, A. Hassanzadeh-Rad, A. Eftekharr, P. Geramifar, M. Eftekhari, Production and clinical applications of radiopharmaceuticals and medical radioisotopes in Iran, Seminars in Nuclear Medicine 46 (4) (2016) 340-358, https://doi.org/10.1053/j.semnuclmed.2016.01.006. 
  24. A. Vakili, A.R. Jalilian, E. Radfar, A. Bahrami-Samani, S. Shirvani-Arani, B. Salami, M. Ghannadi-Maragheh, Optimization of 90Y-antiCD20 preparation for radioimmunotherapy, Iranian Journal of Nuclear Medicine 18 (1) (2010) 16 (n/a). 
  25. D.S. Wang, J.D. Louie, D.Y. Sze, Evidence-based integration of yttrium-90 radioembolization in the contemporary management of hepatic metastases from colorectal cancer, Tech Vasc Interv Radiol 22 (2) (2019) 74-80, https://doi.org/10.1053/j.tvir.2019.02.007. 
  26. N. Gholipour, A.R. Jalilian, A. Khalaj, F. Johari-Daha, K. Yavari, O. Sabzevari, A.R. Khanchi, M. Akhlaghi, Preparation and radiolabeling of a lyophilized (kit) formulation of DOTA-rituximab with 90Y and 111In for domestic radioimmunotherapy and radioscintigraphy of Non-Hodgkin's Lymphoma, DARU Journal of Pharmaceutical Sciences 22 (2014) 58, https://doi.org/10.1186/2008-2231-22-58. 
  27. M.R. Ghahramani, A.A. Garibov, T.N. Agayev, M.A. Mohammadi, A novel way to production yttrium glass microspheres for medical applications, Glass Physics and Chemistry 40 (3) (2014) 283-287, https://doi.org/10.1134/S1087659614030055. 
  28. S.J. Wang, W.Y. Lin, M.N. Chen, B.T. Hsieh, L.H. Shen, Z.T. Tsai, G. Ting, J.T. Chen, W.L. Ho, S. Mirzadeh, F.F. Knapp Jr., Rhenium-188 microspheres: a new radiation synovectomy agent, Nuclear Medicine Communications 19 (5) (1998) 427-433, https://doi.org/10.1097/00006231-199805000-00004. 
  29. C. Bouvry, X. Palard, J. Edeline, V. Ardisson, P. Loyer, E. Garin, et al., Transarterial radioembolisation (TARE) agents beyond 90Y-microspheres, Biomed Res Int 2018 (2018), 1435302, https://doi.org/10.1155/2018/1435302. 
  30. E. Verger, P. Drion, G. Meffre, C. Bernard, L. Duwez, N. Lepareur, et al., 68Ga and 188Re starch-based microparticles as theranostic tool for the hepatocellular carcinoma: radiolabeling and preliminary in vivo rat studies, PLoS ONE 11 (2016), e0164626, https://doi.org/10.1371/journal.pone.0164626. 
  31. A. Cikankowitz, A. Clavreul, C. Tetaud, L. Lemaire, A. Rousseau, N. Lepareur, et al., Characterization of the distribution, retention, and efficacy of internal radiation of 188Re-lipid nanocapsules in an immunocompromised human glioblastoma model, J Neurooncol 131 (2017) 49-58, https://doi.org/10.1007/s11060-016-2289-4. 
  32. B.A. Hrycushko, A.N. Gutierrez, B. Goins, W. Yan, W.T. Phillips, P.M. Otto, et al., Radiobiological characterization of post-lumpectomy focal brachytherapy with lipid nanoparticle-carried radionuclides, Phys Med Biol 56 (2011) 703-719, https://doi.org/10.1088/0031-9155/56/3/011. 
  33. J. Wood, Computational Methods in Reactor Shielding, Chapter 3 - RADIATION SOURCES, Elsevier, 1982, pp. 56-78, https://doi.org/10.1016/B978-0-08-028685-3.50006-X. Available online 2013;. 
  34. ENDF-6, Evaluated Nuclear Data File (ENDF), TENDL, 2019. https://www-nds.iaea.org/exfor/endf.htm. 
  35. A.R. Kachooei, A. Heidari, G. Divband, M.E. Zandinezhad, A. Mousavian, H. Farhangi, B. Aminzadeh, A. Zarifian, F. Bagheri, Z. Badiei, Rhenium-188 radiosynovectomy for chronic haemophilic synovitis: evaluation of its safety and efficacy in haemophilic patients, Haemophilia 26 (1) (2020) 142-150, https://doi.org/10.1111/hae.13880. 
  36. K. Liepe, J.J. Zaknun, A. Padhy, E. Barrenechea, V. Soroa, S. Shrikant, P. Asavatanabodee, M.J. Jeong, M. Dondi, Radiosynovectomy using yttrium-90, phosphorus-32 or rhenium-188 radiocolloids versus corticoid instillation for rheumatoid arthritis of the knee, Annals of Nuclear Medicine 25 (2011) 317-323, https://doi.org/10.1007/s12149-011-0467-1. 
  37. G. Ting, C. Chang, H. Wang, T. Lee, Nanotargeted radionuclides for cancer nuclear imaging and internal radiotherapy, J. Biomed. Biotechnol. (2010), 953537, https://doi.org/10.1155/2010/953537. 
  38. X. Liu, Y. Wang, K. Nakamura, s Kawauchi, A. Akalin, D. Cheng, L. Chen, M. Rusckowski, D.J. Hnatowich, Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In, J. Nucl. Med. 50 (4) (2009) 582-590, https://doi.org/10.2967/jnumed.108.056366. 
  39. J.W. Bulte, Science to practice: can theranostic fullerenes be used to treat brain tumors? Radiology 261 (1) (2011) 1-2, https://doi.org/10.1148/radiol.11111636. 
  40. Z. Li, G. Zhang, H. Shen, L. Zhang, Y. Wang, Synthesis and cell uptake of a novel dual modality 188Re-HGRGD (D) F-CdTe QDs probe, Talanta 85 (2) (2011) 936-942, https://doi.org/10.1016/j.talanta.2011.04.077. 
  41. M. Ashoor, A. Khorshidi, A. Pirouzi, A. Abdollahi, M. Mohsenzadeh, S.M.Z. Barzi, Estimation of Reynolds number on microvasculature capillary bed using diffusion and perfusion MRI: the theoretical and experimental investigations, Eur. Phys. J. Plus 136 (2021) 152, https://doi.org/10.1140/epjp/s13360-021-01145-0. 
  42. M. Ashoor, A. Khorshidi, L. Sarkhosh, Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level, Rep Pract Oncol Radiother 24 (1) (2019) 3-11, https://doi.org/10.1016/j.rpor.2018.09.007. 
  43. I.A. Abbasi, J.H. Zaidi, M. Arif, S. Waheed, M.S. Subhani, Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zirconium: production possibility of no-carrier-added 90Y in a nuclear reactor, Radiochim Acta 94 (8) (2006) 381-384, https://doi.org/10.1524/ract.2006.94.8.381. 
  44. N. Zare, G. Jahanfarnia, A. Khorshidi, J. Soltani, Robustness of optimized FPID controller against uncertainty and disturbance by fractional nonlinear model for research nuclear reactor, Nuclear Engineering and Technology (2020), https://doi.org/10.1016/j.net.2020.03.002. In press. 
  45. S. Mirzadeh, M. Du, A. Beets, F.F. Knapp, Russ). Thermoseparation of neutron-irradiated tungsten from Re and Os, Ind Eng Chem Res 39 (9) (2000) 3169-3172, https://doi.org/10.1021/ie990582x. 
  46. M. Ashoor, A. Khorshidi, L. Sarkhosh, Appraisal of new density coefficient on integrated-nanoparticles concrete in nuclear protection, Kerntechnik 85 (1) (2020) 9-14, https://doi.org/10.3139/124.190016. 
  47. A. Khorshidi, A. Abdollahi, A. Pirouzi, S.H. Hosseini, Band pass filter plan in fluoroscopy for high energy range, SN Appl. Sci. 2 (2020) 90, https://doi.org/10.1007/s42452-019-1885-2. 
  48. M. Rabiei, A. Khorshidi, J. Soltani-Nabipour, Production of Yttrium-86 radioisotope using genetic algorithm and neural network, Biomedical Signal Processing and Control 66 (2021), 102449, https://doi.org/10.1016/j.bspc.2021.102449. 
  49. S. Salari, A. Khorshidi, J. Soltani-Nabipour, Simulation and assessment of 99mTc absorbed dose into internal organs from cardiac perfusion scan, Nuclear Engineering and Technology 55 (1) (2023) 248-253, https://doi.org/10.1016/j.net.2022.08.024. 
  50. H. Imani-Shirvanehdeh, A. Khorshidi, J. Soltani-Nabipour, A. Alipour, K. Arbabi, Design and construction of a cylindrical ionization chamber for reference dosimetry in radiation protection, Iran J Sci Technol Trans Sci 45 (2021) 1837-1841, https://doi.org/10.1007/s40995-021-01153-w. 
  51. M. Ashoor, A. Khorshidi, Point-spread-function enhancement via designing new configuration of collimator in nuclear medicine, Radiation Physics and Chemistry 190 (2022), 109783, https://doi.org/10.1016/j.radphyschem.2021.109783.