Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Radiation Protection Effects of Dendranthema Zawadskii Var. Latilobum (Maxim.) Kitam. Extracts on Blood Cells, Intestine, and Uterus of Female SD Rats Irradiated with Gamma-Ray 10 Gy

구절초 추출물이 감마선 10 Gy에 조사된 암컷 SD Rat의 혈구 및 소장, 자궁에 미치는 방사선 방호효과

  • Sung-Hyun, Joo (Department of Emergency and Disaster Management, Inje University) ;
  • Hae-Suk, Kim (Department of Emergency and Disaster Management, Inje University) ;
  • Sang-Hyun, Jeong (Department of Emergency and Disaster Management, Inje University) ;
  • Jae-Gyeong, Choi (Department of Emergency and Disaster Management, Inje University) ;
  • Seong-Ok, Jin (Department of Emergency and Disaster Management, Inje University) ;
  • Byung-In, Min (Department of Nuclear Applied Engineering, Inje University)
  • 주성현 (인제대학교 재난관리학과) ;
  • 김해숙 (인제대학교 재난관리학과) ;
  • 정상현 (인제대학교 재난관리학과) ;
  • 최제경 (인제대학교 재난관리학과) ;
  • 진성옥 (인제대학교 재난관리학과) ;
  • 민병인 (인제대학교 원자력응용공학부)
  • Received : 2022.10.27
  • Accepted : 2023.01.24
  • Published : 2023.02.28
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Abstract

The purpose of this study is to see the radiation protection effect of the oral injected Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts on the small intestine and uterus of female SD Rat as a natural radiation protection agent. The experimental group was divided into four groups: Normal Control group (NC group), Injected Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts group (DZ group), irradiated group after injecting Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts (DZ+IR group). The whole body of SD Rat was irradiated with gamma-ray 10Gy, and the administration of oral Dendranthema zawadskii var. latilobum (Maxim.) Kitam. Extract was 2 cc (71.56 mg/day/kg) once a day for 2 weeks. For this study, chages in blood cell levels, SOD assay, small intestine and uterus were observed. In the 21st white blood cell level, the DZ+IR group recovered to a normal level, and the IR group didn't. The IR group villus length was lower than other groups on Day 1. IR group was partially recovered, and DZ+IR group was recovered like the NC group on Day 21. In the case of the first-day endometrium, the IR group was thin and the boundary was cloudy, and the DZ+IR group was thicker and the boundary was clearer than the IR group. Day 21 IR group still did not recover, and DZ+IR group recovered like NC group. This is believed to have radiation protection effects in the blood cells and small intestine and uterus of the irradiated female SD Rat, and is expected to be useful for the study of natural radiation protection materials.

Keywords

References

  1. Eliot AJ, Bartels DM. The reaction set, rate constants and g-values for the simulation of the radiolysis of light water over the range 20 degree to 350 degree based on information available. Atomic Energy of Canada. 2008;Report AECL 153-127160-450-001.
  2. Harman D. A theory based on free radical and radiation chemistry. Science of Aging Knowledge Environment. 2002;(37).
  3. Hensley ML, Schuchter LM, Lindley C, Meropol NJ, Cohen GI, Broder G, et al. American society of clinical oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants. Journal of Clinical Oncology. 1999;17(10):3333-55. https://doi.org/10.1200/JCO.1999.17.10.3333
  4. Lee DY, Kang G. Biological effects of radiation and protection measures. Defense and Technology of Korea. 2014;422:162-71.
  5. Lee SJ, Lim TG, So J, Lim JH. A study on morphological characteristics and physiological activities of chrysanthemum zawadskii var. latilobum inhabited in Mt. hwang-mae. Hortic Sci Technol. 2021;39(2):55.
  6. Zhuang ZJ, Shan CW, Li Bo, Pang MX, Wang H, Luo Y, Liu YL, et al. Linarin enriched extract attenuates liver injury and inflammation induced by high-fat high-cholesterol diet in rats. Evidence-Based Complementary and Alternative Medicine. 2017:9.
  7. Mottaghipisheh J, Taghrir H, Dehsheikh AB, Zomorodian K, Irajie C, Sourestani MM, et al. Linarin, a glycosylated flavonoid, with potential therapeutic attributes: A comprehensive review. Journal of Pharmaceuticals. 2021;14:1104.
  8. Lee JH, Park JS. Inhibitory effect of celeriac extract on cancer cell proliferation. Journal of the Korea Convergence Society. 2021;12(9):179-83.
  9. Sun JH, Wang ZD, Chen L, Sun GJ. Hypolipidemic effects and preliminary mechanism of chrysanthemum flavonoids, its main components luteolin and luteoloside in hyperlipidemia rats. Journal of Antioxidants. 2021;10(8):1309.
  10. Olthof MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. Journal of Nutrition. 2001;131(1):66-71. https://doi.org/10.1093/jn/131.1.66
  11. Woo JH, Shin SL, Jeong HS, Lee CH. Antioxidant effect of extracts obtained from three chrysanthemum species. Journal of the Korean Society of Food Science and Nutrition. 2010;39(4):631-6. https://doi.org/10.3746/jkfn.2010.39.4.631
  12. So J, Jung YO, Lee SJ, Lim JH. A study on biological activities on extracts and fractions in chrysanthemum zawadskii var. latilobum (maxim.) kitam. Horticultural Science and Technology. 2021;39(2):171-2.
  13. Kim YJ, Kim SE, Lee HS, Hong SY, Kim SE, Kim YJ, et al. Comparison of linarin content and biological activity in ethanol extraction of chrysanthemum zawadskii. Journal of the Korean Society Food Science and Nutrition. 2016;45(10):1414-21. https://doi.org/10.3746/jkfn.2016.45.10.1414
  14. Onder GO, Balcioglu E, Baran M, Ceyhan A, Cengiz O, Suna PA, et al. The different doses of radiation therapy-induced damage to the ovarian environment in rats. International Journal of Radiation Biology. 2021;97(3):367-75. https://doi.org/10.1080/09553002.2021.1864497
  15. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry. 1974;(47):469-74.