Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Efficacy of flavanone as a treatment for pulmonary fibrosis

Flavanone의 폐섬유증 치료물질로의 유용성

  • Hee Young, Kim (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3) ;
  • Hyerin, Jeong (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3) ;
  • Young Mee, Kim (Department of Biochemistry, School of Medicine, Jeju National University) ;
  • Moonjae, Cho (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3)
  • Received : 2022.09.28
  • Accepted : 2022.11.23
  • Published : 2022.12.31
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Abstract

We examined the lung anti-fibrotic properties of flavanones and flavones, which are flavonoid compounds, in bleomycin- and TGF-β1-stimulated A549 cells. Taken together, treatment with Bleomycin and TGF-β1 increased intracellular ROS by increasing the expression of various NOX families in A549 cells; further, the increased ROS levels resulted in increased fibrosis markers and induced pulmonary fibrosis. Flavonoid treatment has been demonstrated to alleviate or inhibit pulmonary fibrosis by modulating Smad-dependent and -non-dependent TGF-β mechanisms by modulating intracellular NOX expression.

Flavonoid 골격 중 flavanone과 flavone 골격 화합들의 유용성과 가능성에 대해 여러 연구들이 되어있다. 본 연구의 목적은 폐섬유화에 대한 치료물질로서 효능이 있는 flavanone 및 flavone 골격 유래 화합물들을 탐색하는 것에 있다. Flavanone 및 flavone 골격 유래 화합물들이 폐섬유화 억제 효능이 있는지 탐색하기 위해 폐섬유화 유도 물질인 bleomycin과 TGF-β1으로 자극한 A549 세포에서 flavanone 및 flavone 골격 유래 화합물들에 의해 폐섬유증 마커들을 약화시키는지 여부를 확인하였다. 실험 결과를 종합해보면 7,2',3'-trimethoxyflavanone(ICC no. 3), 7,3'-dimethoxyflavone (ICC no. 5), 2'-hydroxyflavanone (ICC no. 6)은 폐섬유화 유도관련 단백질 마커들의 발현을 감소시킨다는 것을 발견하였다. 본 연구에서는 이러한 결과들을 통해 flavanone과 flavone 골격 화합물 중 3가지가 폐섬유증의 예방과 치료에 대한 가능성이 있음을 제시한다.

Keywords

Acknowledgement

이 논문은 2022학년도 제주대학교 교육·연구 및 학생지도비 지원에 의해서 연구되었음.

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