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http://dx.doi.org/10.3839/jabc.2022.046

Efficacy of flavanone as a treatment for pulmonary fibrosis  

Hee Young Kim (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3)
Hyerin Jeong (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3)
Young Mee Kim (Department of Biochemistry, School of Medicine, Jeju National University)
Moonjae Cho (ACHEMBIO Co., Ltd., 508 Jeju Univ. Startup Incubation Center Bldg 3)
Publication Information
Journal of Applied Biological Chemistry / v.65, no.4, 2022 , pp. 357-365 More about this Journal
Abstract
We examined the lung anti-fibrotic properties of flavanones and flavones, which are flavonoid compounds, in bleomycin- and TGF-β1-stimulated A549 cells. Taken together, treatment with Bleomycin and TGF-β1 increased intracellular ROS by increasing the expression of various NOX families in A549 cells; further, the increased ROS levels resulted in increased fibrosis markers and induced pulmonary fibrosis. Flavonoid treatment has been demonstrated to alleviate or inhibit pulmonary fibrosis by modulating Smad-dependent and -non-dependent TGF-β mechanisms by modulating intracellular NOX expression.
Keywords
Bleomycin; Flavanone; Flavone; Flavonoid; Pulmonary fibrosis; TGF-${\beta}1$;
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Times Cited By KSCI : 2  (Citation Analysis)
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