Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Evaluation of Immunomodulatory and Biological Effects of Aquilaria crassna Extracts

침향 추출물의 면역조절 및 생리활성 분석

  • You-Lim, Hwang (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Kwang-Youn, Kim (Korean Medicine Application Center, Korea Institute of Oriental Medicine) ;
  • Sun Nyoung, Yu (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Kwang-Il, Park (Department of Veterinary Physiology, College of Veterinary Medicine, Gyeongsang National University) ;
  • Soon-Cheol, Ahn (Department of Microbiology and Immunology, Pusan National University School of Medicine)
  • 황유림 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 김광연 (한국한의학연구원 한의기술응용센터) ;
  • 유선녕 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 박광일 (경상대학교 수의과대학 수의생리학) ;
  • 안순철 (부산대학교 의과대학 미생물학 및 면역학 교실)
  • Received : 2022.10.12
  • Accepted : 2022.11.09
  • Published : 2022.11.30
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Abstract

Objectives : Aquilaria crassna is a traditional herbal medicine, which is used to treat allergies, diabetes, neurological diseases. Recently, Aquilaria crassna extracts have been reported in anti-bacterial and anti-inflammatory activities. In this study, various solvents fraction of Aquilaria crassna were investigated on various physiological activities. Methods : According to the polarity, the solvents fraction of Aquilaria crassna were confirmed through TLC, and the activities of the extracts were confirmed in anti-diabetes, anti-obesity, whitening, anti-gout, and anti-inflammation. Results : TLC results showed that ACM and ACM/E have similar patterns and most of the components were transferred to ACM/E. Treatment with ACM and ACM/E fraction were significantly decreased the generation of NO in lipopolysaccharide (LPS)-stimulated macrophage cells. Analysis of biological activities such as α-glucosidase, protein tyrosine phosphatase (PTP1B), tyrosinase, xanthine oxidase (XO) and pancreatic lipase inhibition, showed that ACM and ACM/E have more inhibitory effects than other fractions. Conclusions : Therefore, the results of the present study clearly demonstrate that Aquilaria crassna and its constituents might be beneficial in the prevention or treatment of immune-regulating effects.

Keywords

Acknowledgement

본 연구는 부산대학교 기본연구지원사업 (2년) 및 교육부와 한국연구재단의 재원으로 지원을 받아 수행된 3단계 산학협력 선도대학 육성사업(LINK 3.0) (No. 202207830001)에 의하여 연구되었다. 또한, 2022년도 정부(교육부)의 재원으로 한국연구재단 기초연구사업의 지원을 받아 연구하였으며, (No. NRF-2022R1I1A3053818) 이에 감사드립니다.

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