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http://dx.doi.org/10.14374/HFS.2022.30.4.249

Evaluation of Immunomodulatory and Biological Effects of Aquilaria crassna Extracts  

You-Lim, Hwang (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kwang-Youn, Kim (Korean Medicine Application Center, Korea Institute of Oriental Medicine)
Sun Nyoung, Yu (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kwang-Il, Park (Department of Veterinary Physiology, College of Veterinary Medicine, Gyeongsang National University)
Soon-Cheol, Ahn (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Publication Information
Herbal Formula Science / v.30, no.4, 2022 , pp. 249-257 More about this Journal
Abstract
Objectives : Aquilaria crassna is a traditional herbal medicine, which is used to treat allergies, diabetes, neurological diseases. Recently, Aquilaria crassna extracts have been reported in anti-bacterial and anti-inflammatory activities. In this study, various solvents fraction of Aquilaria crassna were investigated on various physiological activities. Methods : According to the polarity, the solvents fraction of Aquilaria crassna were confirmed through TLC, and the activities of the extracts were confirmed in anti-diabetes, anti-obesity, whitening, anti-gout, and anti-inflammation. Results : TLC results showed that ACM and ACM/E have similar patterns and most of the components were transferred to ACM/E. Treatment with ACM and ACM/E fraction were significantly decreased the generation of NO in lipopolysaccharide (LPS)-stimulated macrophage cells. Analysis of biological activities such as α-glucosidase, protein tyrosine phosphatase (PTP1B), tyrosinase, xanthine oxidase (XO) and pancreatic lipase inhibition, showed that ACM and ACM/E have more inhibitory effects than other fractions. Conclusions : Therefore, the results of the present study clearly demonstrate that Aquilaria crassna and its constituents might be beneficial in the prevention or treatment of immune-regulating effects.
Keywords
Aquilaria crassna; Biological activity; immunomodulatory activity;
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