Journal of Interdisciplinary Genomics

Interdisciplinary Society of Genetic & Genomic Medicine (유전의학융합회)
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A Review of HLA Genes in Pharmacogenetics: Risk Assessment of Adverse Drug Reactions

  • Yu, Shinae (Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University College of Medicine)
  • Received : 2020.09.04
  • Accepted : 2020.10.20
  • Published : 2021.04.30
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Abstract

Adverse drug reactions (ADRs) is a hypersensitivity reactions to specific medications, and remain a common and major problem in healthcare. ADRs suchc as drug-induced liver injury and life-threatening severe cutaneous adverse drug reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms can be occurred by uncontrolled expansion of oligoclonal T cells according to genetically predisposing HLA. In this review, I summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.

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References

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