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http://dx.doi.org/10.22742/JIG.2021.3.1.7

A Review of HLA Genes in Pharmacogenetics: Risk Assessment of Adverse Drug Reactions  

Yu, Shinae (Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University College of Medicine)
Publication Information
Journal of Interdisciplinary Genomics / v.3, no.1, 2021 , pp. 7-12 More about this Journal
Abstract
Adverse drug reactions (ADRs) is a hypersensitivity reactions to specific medications, and remain a common and major problem in healthcare. ADRs suchc as drug-induced liver injury and life-threatening severe cutaneous adverse drug reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms can be occurred by uncontrolled expansion of oligoclonal T cells according to genetically predisposing HLA. In this review, I summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.
Keywords
HLA; Pharmacogenetics; Adverse drug reaction;
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