Journal of the Korean Orthopaedic Association (대한정형외과학회지)

Korean Orthopaedic Association (대한정형외과학회)
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Leiomyosarcoma of the Somatic Soft Tissue: Clinical Manifestation and Treatment Results

연부조직에 발생한 평활 근육종의 임상양상 및 치료 결과

  • Kim, Yong Sung (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
  • Kong, Chang-Bae (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
  • Cho, Wan-Hyeong (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
  • Jeon, Dae-Geun (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
  • Kim, Kyung Hoon (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
  • Song, Won Seok (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
  • Received : 2019.08.01
  • Accepted : 2019.11.21
  • Published : 2020.10.30
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Abstract

Purpose: The purpose of this study was to evaluate the treatment outcome of leiomyosarcoma (LMS) of the somatic soft tissue and investigate the prognostic factors. Materials and Methods: Seventy-two patients with soft tissue LMS (extremities and trunk) between 2001 and 2017 were reviewed retrospectively. The local recurrence and metastasis after treatment were examined. The survival rates and prognostic factors affecting survival were investigated. Only patients followed-up more than one year were included. The mean follow-up time was 41 months (range, 7-163 months). Results: The overall survival rates at five-year and 10-year were 73.6% and 66.2%, respectively. The tumor size (p=0.018), grade (p=0.017), and local recurrence (p=0.04) affected survival. Metastases developed in 31.9% (23/72) and the median post metastasis survival was 15.6 months (range, 3-78 months). Conclusion: LMS of the soft tissue developed mainly at the lower extremity. The tumor size, grade, and local recurrence were associated with survival. Post metastatic survival was generally poor despite treatment.

목적: 본 연구의 목적은 연부조직에 발생한 평활 근육종 환자의 치료 결과를 후향적으로 분석하여 생존율과 재발 및 전이의 양상 등 치료 결과를 알아보고 예후에 영향을 미치는 인자를 분석하고자 한다. 대상 및 방법: 2001년 1월부터 2017년 12월까지 본원에서 연부조직에 발생한(사지 및 체간) 평활 근육종으로 치료 받은 72명의 환자를 대상으로 하였다. 치료 후 재발, 전이 발생, 생존율 및 생존의 예후 인자를 조사하였다. 생존자 중 1년 이상 추시되지 않은 증례는 제외하였다. 평균 추시 기간은 41개월(범위, 7-163개월)이었다. 결과: 전체 환자의 5년 생존율은 73.6%, 10년 생존율은 66.2%였다. 생존율에 영향을 미치는 인자는 종양의 크기(p=0.018), 병리학적 등급(p=0.017), 국소재발(p=0.04)이었다. 전이성 병변은 72명의 환자 중 23명(31.9%)의 환자에서 발생하였으며 전이 후 사망까지의 중간값은 15.6개월(범위, 3-78개월)이었다. 결론: 연부조직에 발생하는 평활 근육종은 주로 하지에 발생하며 종양의 크기, 병리학적 등급, 국소재발이 생존율에 영향을 미치고, 전이 후 생존율은 치료에도 불구하고 불량하였다.

Keywords

References

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