Fig. 1. Structures of Arbutin and Glabridin
Fig. 2. Effect of Arbutin(a), Oil soluble licorice(b) and mixture(c) on the viability of B16 melanoma cells by MTT assay.
Fig. 3. Inhibitory effects of Arbutin(a), Oli soluble licorice(b) and Mixture(c) on the activity of mushroom tyrosinase.
Fig. 4. Inhibitory effects of Arbutin(a), Oli soluble licorice(b) and Mixture(c) on the tyrosinase activity in B16 melanoma cells.
Fig. 5. Inhibitory effects of Arbutin(a), Oli soluble licorice extract(b) and Mixture(c) on the melanin synthesis in B16 melanoma cells.
Table 1. Ingredients and content of whitening products
References
- K. Maeda, M, Fukuda, "Arbutin: mechanism of its depigmenting action in human melanocyte culture", Journal of Pharmacology and Experimental therapeutics, Vol. 276, No. 2, pp. 765-774, (1996).
- F. Toshio, S. Kazue, N. Taro, S. Hiroshi, "Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra", Fitoterapia, Vol. 74, No. 7, pp. 624-629, (2003). https://doi.org/10.1016/S0367-326X(03)00164-3
- H. H. Kirstein, H. S. Honore, K. Marianne, P. G. Merete, "Comparison of highperformance liquid chromatography and capillary electrophoresis methods for quantitative determination of glycyrrhizinic acid in pharmaceutical preparations", European Journal of Pharmaceutical Sciences, Vol. 9, No. 1, pp. 41-46, (1999). https://doi.org/10.1016/S0928-0987(99)00040-8
- J Vaya, P. A. Belinky, M. Aviram, "Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation", Free Radical Biology and Medicine, Vol. 23, No. 2, pp. 302-315, (1997). https://doi.org/10.1016/S0891-5849(97)00089-0
- T. Yokota, H. Nishio, Y. Kubota, M. Mizoguchi, "The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation", Pigment Cell Research, Vio. 11, No. 6, pp. 355-416, (1998). https://doi.org/10.1111/j.1600-0749.1998.tb00494.x
- S. Jun, G. Keiichi, N. Fumio, K. Shigeyuki, M. Kousaku, "Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola", Journal of bioscience and bioengineering, Vol. 90, No. 4 442-446, (2000). https://doi.org/10.1016/S1389-1723(01)80016-5
- R. Saruno, F. Kato, T. Ikeno, "Kojic acid, a tyrosinase inhibitor from Aspergillus albus". Bioscience, Biotechnology, and Biochemistry, Vol. 43, No. 6, pp. 1337-1338, (1979).
- J. H. Park, Y. G. Shin, U. K. Shin, S. K. Baek, S. K. Lee, M. H. Chung, Y. L. Park, "Tyrosinase inhibition activity of some herbal drug" Yakhak Hoiji, VOl. 41, No. 4, pp. 518-523, (1997).
- Y. H. Lee, N. H. Lim, M. S. Jung, J. H. Kim, S. S. Shim, "Chemical Stability and Whitening Activity of Mixture of Functional Ingredients", Journal of the society of cosmetic scientists of Korea, Vol. 31, No. 4, pp. 295-304, (2005).
- A. M. Sieuwerts, J. G Klijn, H. A. Peters, J. A. Foekens, "The MTT tetrazolium salt assay scrutinized: how to use this assay reliably to measure metabolic activity of cell cultures in vitro for the assessment of growth characteristics, IC50-values and cell survival", journal of the Forum of European Clinical Chemistry Societies, Vol. 33, No. 7, pp. 813-836, (1995).
- V. J Hearing, "Bio chemical control of melanogenesis and melanoma organization", Journal of Investigative Dermatology Symposium Proceedings, Vol. 4, No. 1, pp. 24-32, (1999). https://doi.org/10.1038/sj.jidsp.5640176
- S. J. Kim, K. H. Son, H. W. Chang, S. S. Kang, H. P. Kim, Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens. Biological and Pharmaceutical Bulletin, 26(9), pp. 1348-1350, (2003). https://doi.org/10.1248/bpb.26.1348
- V. Jiři, D. Jiři, M. Bohuslav.. "A spectrophotometric assay for mammalian tyrosinase utilizing the formation of melanochrome from L-dopa." Anal Biochem, 146(2), pp. 405-410, (1985). https://doi.org/10.1016/0003-2697(85)90559-7
- J. K. Son, "Isolation and structure determination of a new tetralone glucoside from the roots of Juglans mabndschurica", Arch. Pharm. Res, Vol. 18, pp. 203-205, (1995). https://doi.org/10.1007/BF02979196
- W. Englaro, R. Rezzonico, M, Durand-Clement, D. Lallemand, J. P. Ortonne, R. Ballotti, "Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells:, J Biol Chem, Vol. 270, No. 41, pp. 24315-24320, (1995). https://doi.org/10.1074/jbc.270.41.24315
- K. U. Schallreuter, S. Kothari, B. Chavan, J. D. Spencer, "Regulation of melanogenesiscontroversies and new concepts", Exp Dermatol, Vol. 17, No. 5, pp. 395-404, (2008). https://doi.org/10.1111/j.1600-0625.2007.00675.x