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http://dx.doi.org/10.12925/jkocs.2019.36.2.635

Study for Whitening Activity of Mixture of Arbutin and Oil Soluble Licorice Extract  

Jang, Hye In (Department. of Oriental Medical and Herbal Cosmetic Sciences, Semyung University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.2, 2019 , pp. 635-644 More about this Journal
Abstract
The aim of this study was to investigate whitening effect of combination between arbutine and oil soluble licorice extract. Inhibitory effects of arbutin and oil soluble licorice extract against tyrosinase activity and melanogenesis in B16 melanoma cells were assessed in vitro to determine whitening effect. MTT assay with B16 melanoma cells showed that mixture (arbutin and oil soluble) was not each concentration. Both oil soluble licorice extract and arbutin induced dose-dependent inhibition of mushroom tyrosinase activity. Various concentrations (oil soluble extract : arbutin = 1:1. 1:1.5, 1:2, 1:2.5, 1:5) of mixtures also significantly inhibited tyrosinase activity in B16 melanoma cells by 40-51%. In addition, the mixtures reduced the melanin contents of B16 melanoma cells by more than 50% at each concentration. These results suggest that mixtures of arbutin and oil soluble licorice extract are very effective whitening ingredients.
Keywords
Abutin; Oil-soluble licorice Extract; Mixture; Whitening effect; Tyrosinase inhibitor;
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