Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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The effect of Lycii radicis CORTEX extracts on the Rheumatoid arthritis related factors

지골피 추출물이 류마티스관절염 관련 매개체에 미치는 영향

  • Received : 2019.09.08
  • Accepted : 2019.12.28
  • Published : 2019.12.30
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Abstract

The present study aimed to evaluate the effect of Lycii radicis CORTEX extract on rheumatoid related factors in CIA-induced Rheumatoid Arthritis model of DBA/1 mice. Lycii radicis CORTEX extract was administered orally at doses of 200 mg/kg/day for 4 weeks after direct injection of CIA into the mice' right paw. We evaluated the treatment effects based on serum biomarkers, morphological and histopathological analyses of the paw. Compared with those in control mice, the Lycii radicis CORTEX extract treatments significantly reduced the serum concentration of cytokine, kemokine and immunoglobulin levels. In addition, the Lycii radicis CORTEX extract treatments effectively preserved the paw bone joint, that in the H&E staining and masson-trichrome staining showed that there were histopathological improvements in Lycii radicis CORTEX extract treated group compared to those of control group. The results indicate that Lycii radicis CORTEX extract alleviated rheumatoid arthritis symptoms. Thus, Lycii radicis CORTEX extract may be a novel therapeutic option for the management of rheumatoid arthritis.

본 연구는 CIA로 유도된 류마티스 관절염 모델에서 지골피 추출물이 류마티스관절염 관련 인자에 미치는 영향을 평가하였다. 동물 모델에 류마티스관절염을 유발한 후 지골피 추출물을 4주간 200 mg/kg/day 용량으로 경구 투여하였다. 이후 혈액, 방사선 및 조직 분석에 기초하여 효과를 평가하였다. 그 결과, 대조군에 비해 지골피 추출물은 사이토카인, 케모카인 및 면역글로불린 생성을 유의하게 감소시켰다. 또한, 지골피 추출물은 중족골을 효과적으로 보존하였으며, H&E 및 M&T 염색에서도 대조군에 비해 조직 병리학적 개선이 있음을 보여주었다. 이와 같은 결과는 지골피 추출물이 류마티스관절염 증상을 완화시켰음을 나타내고 있다. 따라서 지골피 추출물은 류마티스 관절염 관리를 위한 새로운 치료옵션이 될 수 있다.

Keywords

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