Journal of Korean Neurosurgical Society

  • 제61권6호
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  • Pages.753-760
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  • 2018
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Cyberknife Dosimetric Planning Using a Dose-Limiting Shell Method for Brain Metastases

  • Yoon, Kyoung Jun (Radiosurgery Center, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Cho, Byungchul (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kwak, Jung Won (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Doheui (Radiosurgery Center, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kwon, Do Hoon (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Seung Do (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-Wook (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Chang Jin (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Roh, Sung Woo (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Cho, Young Hyun (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2018.04.02
  • 심사 : 2018.08.04
  • 발행 : 2018.11.01
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초록

Objective : We investigated the effect of optimization in dose-limiting shell method on the dosimetric quality of CyberKnife (CK) plans in treating brain metastases (BMs). Methods : We selected 19 BMs previously treated using CK between 2014 and 2015. The original CK plans ($CK_{original}$) had been produced using 1 to 3 dose-limiting shells : one at the prescription isodose level (PIDL) for dose conformity and the others at low-isodose levels (10-30% of prescription dose) for dose spillage. In each case, a modified CK plan ($CK_{modified}$) was generated using 5 dose-limiting shells : one at the PIDL, another at intermediate isodose level (50% of prescription dose) for steeper dose fall-off, and the others at low-isodose levels, with an optimized shell-dilation size based on our experience. A Gamma Knife (GK) plan was also produced using the original contour set. Thus, three data sets of dosimetric parameters were generated and compared. Results : There were no differences in the conformity indices among the $CK_{original}$, $CK_{modified}$, and GK plans (mean 1.22, 1.18, and 1.24, respectively; p=0.079) and tumor coverage (mean 99.5%, 99.5%, and 99.4%, respectively; p=0.177), whereas the $CK_{modified}$ plans produced significantly smaller normal tissue volumes receiving 50% of prescription dose than those produced by the $CK_{original}$ plans (p<0.001), with no statistical differences in those volumes compared with GK plans (p=0.345). Conclusion : These results indicate that significantly steeper dose fall-off is able to be achieved in the CK system by optimizing the shell function while maintaining high conformity of dose to tumor.

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참고문헌

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