DOI QR코드

DOI QR Code

Complete genome of the multidrug-resistant Escherichia coli strain KBN10P04869 isolated from a patient with acute myeloid leukemia

급성백혈병 환자에서 분리된 다제내성 대장균 KBN10P04869의 유전체 염기서열분석

  • Kim, Yu Kyung (Department of Clinical Pathology, School of Medicine, Kyungpook National University) ;
  • Lee, Won Kil (Department of Clinical Pathology, School of Medicine, Kyungpook National University) ;
  • Song, Kyung Eun (Department of Clinical Pathology, School of Medicine, Kyungpook National University)
  • 김유경 (경북대학교 의과대학 임상병리학교실) ;
  • 이원길 (경북대학교 의과대학 임상병리학교실) ;
  • 송경은 (경북대학교 의과대학 임상병리학교실)
  • Received : 2018.08.08
  • Accepted : 2018.09.17
  • Published : 2018.12.31

Abstract

Recently, we isolated a multidrug-resistant Escherichia coli strain KBN10P04869 from a patient with acute myeloid leukemia. We report the complete genome of this strain which consists of 5,104,264 bp with 4,457 protein-coding genes, 88 tRNAs, and 22 rRNAs, and the co-occurrence of multidrug- resistant genes including $^{bla}CMY-2$, $^{bla}TEM-1$, $^{bla}CTX-M-15$, $^{bla}NDM-5$, and $^{bla}OXA-18$.

저자들은 최근 급성골수성백혈병 환자로부터 다제내성대장균 균주 KBN10P04869를 분리했다. 균주는 4,457개의 단백질 코딩 유전자, 88개의 운반 RNA, 22개의 리보솜 RNA를 포함하는 5,104,264 염기쌍으로 구성되고, $^{bla}CMY-2$, $^{bla}TEM-1$, $^{bla}CTX-M-15$, $^{bla}NDM-5$, $^{bla}OXA-18$를 포함한 다제내성유전자를 가지고 있다. 저자들은 이 균주의 총유전체를 보고하는 바이다.

Keywords

Table 1. General features of E. coli strain KBN10P04869 complete genome

MSMHBQ_2018_v54n4_442_t0001.png 이미지

Table 2. Results of antimicrobial test and resistant genes

MSMHBQ_2018_v54n4_442_t0002.png 이미지

References

  1. Chin CS, Alexander DH, Marks P, Klammer AA, Drake J, Heiner C, Clum A, Copeland A, Huddleston J, Eichler EE, et al. 2013. Nonhybrid, finished microbial genome assemblies from longread SMRT sequencing data. Nat. Methods 10, 563-569. https://doi.org/10.1038/nmeth.2474
  2. Hawkey PM and Jones AM. 2009. The changing epidemiology of resistance. J. Antimicrob. Chemother. 64, i3-i10. https://doi.org/10.1093/jac/dkp256
  3. Javaloyas M, Garcia-Somoza D, and Gudiol F. 2002. Epidemiology and prognosis of bacteremia: a 10-y study in a community hospital. Scand. J. Infect. Dis. 34, 436-441. https://doi.org/10.1080/00365540110080629
  4. Rodriguez-Bano J, Navarro MD, Romero L, Muniain MA, Perea EJ, Perez-Cano R, Hernandez JR, and Pascual A. 2006. Clinical and molecular epidemiology of extended-spectrum ${\beta}$-lactamase-producing Escherichia coli as a cause of nosocomial infection or colonization: implications for control. Clin. Infect. Dis. 42, 37-45. https://doi.org/10.1086/498519