Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Quantitative Comparison of 1H-MRS Spectra Depending on the Paramagnetic Gadolinium Contrast Agent(GBCA) Injection

가돌리늄 조영제 주입에 따른 1H-MRS spectrum의 정량적 비교

  • Choi, Kwan-Woo (Department of Radiology, Asan Medical Center) ;
  • Son, Soon-Yong (Department of Radiotechnology, Wonkwang Health Science University) ;
  • Yoo, Beong-Gyu (Department of Radiotechnology, Wonkwang Health Science University)
  • 최관우 (서울아산병원 영상의학과) ;
  • 손순룡 (원광보건대학교 방사선과) ;
  • 유병규 (원광보건대학교 방사선과)
  • Received : 2017.11.15
  • Accepted : 2017.12.31
  • Published : 2017.12.31
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Abstract

This study evaluated the effect of gadolinium contrast agents on the spectrum of metabolites during $^1H-MRS$ of brain and to investigate whether the contrast agents injected before MR spectroscopy significantly affect the estimated peaks of MRS. From January to May 2017, brain MR spectroscopy was performed on 30 patients to compare the spectrum before and after contrast injection of the brain white matter tissue. As a result, the spectrum of metabolites decreased after the paramagnetic contrast agents injected. However, it was not statistically significant which indicated that the use of contrast agent did not meaningfully affect the spectrum of metabolites. In conclusion, the use of the paramagnetic contrast before the acquisition of the spectroscopy may aid voxel positioning especially when it is difficult to determine the exact location of the lesion or the contrast is low.

본 연구는 1H-MRS 검사 시 조영제 사용이 대사물질의 spectrum에 어떤 영향을 미치는지 비교 분석함으로써, 조영제 주입 후 MRS 시행의 가능성을 알아보고자 하였다. 연구방법은 2017년 1월부터 동년 5월까지 뇌 MRI 검사를 시행한 30명을 대상으로, 조영제 주입 전, 후 전두엽 백질 부분의 spectrum을 획득하여 뇌 조직의 대사물질 spectrum을 비교평가 하였다. 연구결과, 조영제를 주입할 경우 각 대사물질의 spectrum은 통계적으로 의미가 없어 조영제 사용이 대사물질의 spectrum에 영향을 미치지 않음을 알 수 있었다. 결론적으로 대조도가 떨어져 병변의 위치파악이 힘든 경우 정확한 위치의 spectrum을 얻기 위해선 조영제를 사용하여 대조도를 높인 다음 MRS를 시행하는 것이 바람직 할 것으로 사료된다.

Keywords

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