대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제3권2호
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  • Pages.116-121
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  • 2017
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  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
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Novel organic catalysts for nucleophilic fluorination including F-18 radiofluorination

  • Na, Hyeon Su (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Kim, Dong Wook (Department of Chemistry and Chemical Engineering, Inha University)
  • 투고 : 2017.12.11
  • 심사 : 2017.12.24
  • 발행 : 2017.12.30
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초록

To overcome the low reactivity and solubility of alkali metal fluorides (MFs), various types of phase transfer catalysts (PTCs) have been developed over the last decades. However, since the fluoride activated by such PTC sometimes has a strong basicity, it may cause various side reactions such as elimination reaction or hydroxylation reaction in the nucleophilic fluorination reaction. Also, they may cause separation problems in the compound purification process. In recent advanced study, various PTCs have been developed to solve these problem of conventional catalyst. In this review, we would like to introduce three kinds of novel multifunctional organic catalysts such as bis-tert-alcohol-functionalized crown-6-calix[4]arene (BACCA), easy separable pyrene-tagged ionic liquid (PIL) by reduced graphene oxide (rGO), and tri-tert-butanolamine organic catalyst.

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