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http://dx.doi.org/10.22643/JRMP.2017.3.2.116

Novel organic catalysts for nucleophilic fluorination including F-18 radiofluorination  

Na, Hyeon Su (Department of Chemistry and Chemical Engineering, Inha University)
Kim, Dong Wook (Department of Chemistry and Chemical Engineering, Inha University)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.3, no.2, 2017 , pp. 116-121 More about this Journal
Abstract
To overcome the low reactivity and solubility of alkali metal fluorides (MFs), various types of phase transfer catalysts (PTCs) have been developed over the last decades. However, since the fluoride activated by such PTC sometimes has a strong basicity, it may cause various side reactions such as elimination reaction or hydroxylation reaction in the nucleophilic fluorination reaction. Also, they may cause separation problems in the compound purification process. In recent advanced study, various PTCs have been developed to solve these problem of conventional catalyst. In this review, we would like to introduce three kinds of novel multifunctional organic catalysts such as bis-tert-alcohol-functionalized crown-6-calix[4]arene (BACCA), easy separable pyrene-tagged ionic liquid (PIL) by reduced graphene oxide (rGO), and tri-tert-butanolamine organic catalyst.
Keywords
Nucleophilic fluorination; Phase transfer catalysts; Flexible fluoride; [$^{18}F$]Fluoride; Ionic liquid; Alkali metal fluoride;
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