Journal of Korean Society on Water Environment (한국물환경학회지)

Korean Society on Water Environment (한국물환경학회)
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Determination of Veterinary Antibiotic Residues: III. Analytical Methods_A Review

시료 중 잔류 항생제 분석 방법: III. 기기 분석 방법

  • Kim, Chansik (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Ryu, Hong-Duck (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Chung, Eu Gene (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Kim, Yongseok (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Rhew, Doug Hee (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research)
  • 김찬식 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 류홍덕 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 정유진 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 김용석 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 류덕희 (국립환경과학원 물환경연구부 유역총량연구과)
  • Received : 2016.08.23
  • Accepted : 2016.11.21
  • Published : 2016.11.30
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Abstract

This study explored the analytical conditions for 21 veterinary antibiotics which have been popularly sold in South Korea in 2014 but have not yet been targeted in EPA method 1694. Most of the selected antibiotics were separated by a reverse-phase C18 column with a combination of (buffered) water and organic polar solvent, which was commonly methanol and acetonitrile in the gradient elution mode. Volatile additives such as formic acid, ammonium acetate and ammonium formate were usually added to the mobile phases to minimize asymmetrical and tailing of antibiotics' peaks and to increase their ionization in mass spectrometry. The analytical methods of aminoglycoside antibiotics were distinct from those of the other antibiotics in terms of adoption of ion-pair chromatography (IPC) and hydrophilic interaction liquid chromatography (HILIC) capable of retaining and separating extremely polar compounds due to their hydrophilicity. Trifluoroacetic acid or heptafluorobutyric acid was frequently added to the mobile phase as an ion-pair reagent for the IPC. Tandem mass spectrometry was numerously applied to the detection of antibiotics using positive electrospray ionization (ESI) and the selected reaction monitoring (SRM) mode. All reviewed analytical methods had been/were validated by evaluating recovery, limits of detection and quantification, decision limit or detection capability of the methods.

Keywords

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