Journal of Korean Society on Water Environment (한국물환경학회지)

Korean Society on Water Environment (한국물환경학회)
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Determination of Antibiotic Residues: II. Extraction and Clean-up Methods for Liquid Samples_A Review

시료 중 잔류 항생제 분석 방법: II. 액상 시료 전처리 방법

  • Kim, Chansik (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Ryu, Hong-Duck (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Chung, Eu Gene (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Kim, Yongseok (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research) ;
  • Rhew, Doug Hee (Watershed and Total Load Management Research Division, Water Environment Research Department, National Institute of Environmental Research)
  • 김찬식 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 류홍덕 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 정유진 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 김용석 (국립환경과학원 물환경연구부 유역총량연구과) ;
  • 류덕희 (국립환경과학원 물환경연구부 유역총량연구과)
  • Received : 2016.07.11
  • Accepted : 2016.11.21
  • Published : 2016.11.30
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Abstract

Increased attention has been paid to the presence of veterinary antibiotics in various environmental matrices due to their toxicological behavior in the ecosystem and development of antibiotic-resistant strains of pathogenic bacteria. In the this review, 37 target antimicrobials were selected based on annual sales of antibiotics for livestock in South Korea 2014. Also, extraction and clean-up methods for the determination of the antibiotic residues in liquid samples including water, milk, and honey were comprehensively reviewed in the literature. Solid-phase extraction (SPE) was commonly used as a pre-treatment method for the samples. Most of the analytes were extracted in acidic conditions (2.5~4.0) except for aminoglycosides, which were extracted in neutral conditions (7.0~8.0). ${\beta}-Lactams$ showed the highest recoveries in neutral pH due to their degradation characteristics in acidic media. Starta-X, Oasis HLB, and Oasis MCX were frequently applied as an SPE cartridge and Oasis HLB showed the highest recoveries for the majority of antibiotic classes. The homogenized honey and milk were extracted by mixing with acids for deproteinization. Solids and other interfering substances in the extract were eliminated by centrifugation followed by membrane filtration or SPE before injection into HPLC.

Keywords

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