Journal of the Korean Magnetics Society (한국자기학회지)

The Korean Magnetics Society (한국자기학회)
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Detection Property of Red Blood Cell-Magnetic Beads Using Micro Coil-Channeland GMR-SV Device

마이크로 코일-채널과 GMR-SV 소자를 이용한 적혈구-자성비드 검출 특성연구

  • Park, Ji-Soo (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Kim, Nu-Ri (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Jung, Hyun-Jun (Department of Oriental Biomedical Engineering, Sangji University) ;
  • Lee, Sang-Suk (Department of Oriental Biomedical Engineering, Sangji University)
  • 박지수 (상지대학교 한방의료공학과) ;
  • 김누리 (상지대학교 한방의료공학과) ;
  • 정현준 (상지대학교 한방의료공학과) ;
  • 이상석 (상지대학교 한방의료공학과)
  • Received : 2015.01.15
  • Accepted : 2015.02.12
  • Published : 2015.02.28
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Abstract

The micro device, coil, and channel for the biosensor integrated with the GMR-SV device based on the antiferromagnetic IrMn layer was fabricated by the light lithography process. When RBCs coupled with several magnetic beads with a diameter of $1{\mu}m$ passed on the micro channel, the movement of $RBC+{\mu}Beads$ is controlled by the electrical AC input signal. The $RBC+{\mu}Beads$ having a micro-magnetic field captured above the GMR-SV device is changed as the output signals for detection status. From these results, the GMR-SV device having the width magnitude of a few micron size can be applied as the biosensor for the analysis of a new magnetic property as the membrane's deformation of RBC coupled to magnetic beads.

광 리소그래피 공정을 이용하여 GMR-SV(Giant magnetoresistance-Spin valve) 다층박막 위에 마이크로 크기의 바이오센서용 소자와 코일-채널을 적층으로 각각 제작하였다. 직경 $1{\mu}m$ 크기인 여러 개의 자성비드가 결합된 적혈구가 마이크로 채널로 지나갈 때 코일에 인가하는 AC 신호로 정지 또는 통과하는 적혈구 움직임을 조절하였다. GMR-SV 소자 위에 포획된 적혈구-자성비드가 갖는 미세자기장은 자기저항비를 변화시켜 검출용 출력신호 특성으로 나타났다. 이것을 이용하여 자성비드를 결합한 적혈구의 막 변형에 따른 운동 특성을 분석하는 바이오센서로 활용할 수 있음을 보여주었다.

Keywords

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