Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Diffusion-weighted and Dynamic Contrast-enhanced MRI of Metastatic Bone Tumors: Correlation of the Apparent Diffusion Coefficient, $K^{trans}$ and $v_e$ values

골전이암의 확산강조영상과 역동적 조영증강 자기공명영상: 겉보기 확산계수, $K^{trans}$와 $v_e$ 값들의 상관관계

  • Koo, Ji Hyun (Department of Radiology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Yoon, Young Cheol (Department of Radiology, Samsung Medical Center, Sungkyunkwan University, College of Medicine) ;
  • Kim, Jae Hoon (Department of Radiology, Samsung Medical Center, Sungkyunkwan University, College of Medicine)
  • 구지현 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 윤영철 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 김재훈 (성균관대학교 의과대학 삼성서울병원 영상의학과)
  • Received : 2013.09.20
  • Accepted : 2014.03.11
  • Published : 2014.03.30
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Abstract

Purpose : To investigate whether quantitative parameters derived from Diffusion-weighted magnetic resonance imaging (DW-MRI) correlate with those of Dynamic contrast-enhanced MRI (DCE-MRI). Materials and Methods: Thirteen patients with pathologically or clinically proven bony metastasis who had undergone MRI prior to treatment were included. The voxel size was $1.367{\times}1.367{\times}5mm$. A dominant tumor was selected and the apparent diffusion coefficient (ADC) value and DCE-MRI parameters were obtained by matching voxels. DCE-MRI data were analyzed yielding estimates of $K^{trans}$ (volume transfer constant) and $v_e$. (extravascular extracellular volume fraction). Statistical analysis of ADC, $K^{trans}$, and $v_e$ value was conducted using Pearson correlation analyses. Results: Fifteen lesions in pelvic bones were evaluated. Of these, 11 showed a statistically significant correlation (P<0.05) between ADC and $K^{trans}$. The ADC and $K^{trans}$ were inversely related in 7 lesions and positively related in 4 lesions. This did not depend on the primary cancer or site of metastasis. The ADC and $v_e$ of 9 lesions correlated significantly. Of these, 4 lesions were inversely related and 5 lesions were positively related. Conclusion: Unlike our theoretic hypothesis, there was no consistent correlation between ADC values and $K^{trans}$ or between ADC values and $v_e$ in metastatic bone tumors.

목적: 확산강조영상 (DW-MRI)과 역동적 조영증강 자기공명영상 (DCE-MRI)에서 도출한 정량적 매개변수들이 서로 연관되어 있는지 알아보고자 하였다. 대상과 방법: 치료시작 전 DWI와 DCE-MRI를 시행한 조직학적으로 혹은 임상적으로 진단된 골전이암을 가진 13명의 환자를 대상으로 하였다. 주 병변의 겉보기 확산계수 (ADC) 그리고 관류지수 중 $K^{trans}$와 $V_e$ 값을 측정하여 Pearson 연관분석을 사용하여 통계적으로 분석하였다. 결과: 15개의 병변 중 11개는 ADC와 $K^{trans}$ 값 간에 유의한 상관관계를 보였다. 이 중 7개의 병변은 음의 연관성을, 그리고 4개는 양의 연관성을 보였다. 9개의 병변은 ADC와 $V_e$ 값 간에 유의한 상관관계를 보였다. 이 중 4개는 음의 연관성을, 그리고 5개는 양의 연관성을 보였다. 결론: 골전이암의 ADC 값과 $K^{trans}$ 값, 혹은 ADC 값과 $V_e$ 값은 일정한 연관성이 없었다.

Keywords

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