Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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소아청소년 틱장애 환자의 B림프구에서 D8/17의 발현

D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder

  • 오영근 (전북대학교 의학전문대학원 정신과학교실) ;
  • 박태원 (전북대학교 의학전문대학원 정신과학교실) ;
  • 정용우 (고려대학교 약학대학 약학과) ;
  • 정상근 (전북대학교 의학전문대학원 정신과학교실) ;
  • 정영철 (전북대학교 의학전문대학원 정신과학교실) ;
  • 양종철 (전북대학교 의학전문대학원 정신과학교실)
  • Oh, Young-Gun (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences) ;
  • Park, Tae-Won (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences) ;
  • Jung, Yong Woo (Department of Pharmacy, Korea University) ;
  • Chung, Sang-Keun (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences) ;
  • Chung, Young-Chul (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences) ;
  • Yang, Jong-Chul (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
  • 투고 : 2013.07.24
  • 심사 : 2013.09.17
  • 발행 : 2013.09.30
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초록

Objectives : It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms. Methods : The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis. Results : In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups. Conclusion : The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.

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참고문헌

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