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http://dx.doi.org/10.5765/jkacap.2013.24.3.151

D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder  

Oh, Young-Gun (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
Park, Tae-Won (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
Jung, Yong Woo (Department of Pharmacy, Korea University)
Chung, Sang-Keun (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
Chung, Young-Chul (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
Yang, Jong-Chul (Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences)
Publication Information
Journal of the Korean Academy of Child and Adolescent Psychiatry / v.24, no.3, 2013 , pp. 151-156 More about this Journal
Abstract
Objectives : It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms. Methods : The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis. Results : In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups. Conclusion : The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.
Keywords
Tic Disorder; D8/17; ASO; PANDAS; FACS;
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