Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Synthesis of Molecularly Imprinted Polymers for Chiral (S)-Ibuprofen and Their Molecular Recognition Mechanism

키랄(S)-이부푸로펜 함유 고분자의 합성과 제조된 고분자의 분자 인식 메카니즘

  • Huangfu, Fengyun (Textile Auxiliaries Company Ltd. of Tianjin Polytechnic University) ;
  • Wang, Bing (State Key Laboratory of Hollow Fiber Membrane Materials and Processes (Tianjin Polytechnic University), School of Environmental and Chemical Engineering, Tianjin Polytechnic University) ;
  • Sun, Yan (State Key Laboratory of Hollow Fiber Membrane Materials and Processes (Tianjin Polytechnic University), School of Environmental and Chemical Engineering, Tianjin Polytechnic University)
  • Received : 2012.09.06
  • Accepted : 2012.12.02
  • Published : 2013.05.25
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Abstract

A group of molecularly imprinted polymers (MIPs) with specific recognition for chiral (S)-ibuprofen were successfully prepared based on hydrogen bonds, utilizing ${\alpha}$-methacrylic acid as a functional monomer. The IR analysis of MIPs showed that the blue- and red-shifted hydrogen bonds were formed between templates and functional monomers in the process of self-assembly imprinting and re-recognition, respectively. According to UV-Vis analysis, we found that the ratio of host-guest complexes between template molecule and functional monomer was 1:1. The effect of cross-linker's quantity on the polymerization was studied by transmission electron microscope (TEM). The adsorption selectivity experiments indicated that MIPs exhibited higher selectivity to (S)-ibuprofen than those to ketoprofen and (R)-ibuprofen, (S)-ibuprofen's structural analogs.

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References

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