Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Characterization and Release Behavior of Polymersomes of PEG-Poly(fumaric-sebacic acids)-PEG Triblock Copolymer in Aqueous Solution

PEG-Poly(fumaric-sebacic acids)-PEG 삼중 블록 공중합체로 수용액에서 만들어진 폴리머솜의 분석과 방출특성

  • Pourhosseini, Pouneh S. (Department of Biology, Faculty of Science, Buali-Sina University) ;
  • Saboury, Ali A. (Institute of Biochemistry and Biophysics, University of Tehran) ;
  • Najafi, Farhood (Department of Resin and Additives, Institute for Color Science and Technology) ;
  • Divsalar, Adeleh (Department of Biological Sciences, Tarbiat Moallem University) ;
  • Sarbolouki, Mohammad N. (Institute of Biochemistry and Biophysics, University of Tehran)
  • Received : 2012.09.20
  • Accepted : 2012.12.06
  • Published : 2013.05.25
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Abstract

Polymersomes made of biodegradable triblock copolymers based on poly(fumaric acid-co-sebacoyl chloride)/PEG (PEG-co-P(FA/SC)-co-PEG) were prepared and studied in aqueous solutions. TEM confirmed the formation of vesicles in aqueous media. Aggregation behavior of the copolymers was studied by fluorescence spectroscopy of 8-anilino-1-naphthalenesulfonic acid, and the critical aggregation concentration (c.a.c.) of the copolymer was found to be ${\sim}26.2{\mu}M$ indicating desirable stability of the vesicles. Dynamic light scattering revealed that the size of the vesicles was distributed within the range of 170-270 nm. Turbidity measurements confirmed the relative short-term stability of the polymersomes. Carboxyfluorescein, a hydrophilic compound, was simply encapsulated in the vesicles during polymersome preparation. The release of encapsulant from the polymersomes at 25 and $37^{\circ}C$ lasted about 3 weeks, and the rate of release followed a first-order kinetics. The release is speculated to be primarily carried out through diffusion. These results confirm that these polymersomes are promising as controlled-release carriers of various drugs.

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