Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Regional Brain Perfusion before and after Treatment with Methylphenidate According to the MspI Polymorphism of the Alpha-2A Adrenergic Receptor Gene in Children with Attention-Deficit Hyperactivity Disorder

주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교

  • Park, Subin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Bae, Jeong-Hoon (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Yang, Young-Hui (Department of Psychiatry, College of Medicine, Pusan National University) ;
  • Oh, Seungmin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Hong, Soon-Beom (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Park, Min-Heyon (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Boong-Nyun (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Yoo, Hee-Jeong (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine) ;
  • Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
  • 박수빈 (서울대학교 의과대학 정신과학교실) ;
  • 배정훈 (서울대학교 의과대학 정신과학교실) ;
  • 김재원 (서울대학교 의과대학 정신과학교실) ;
  • 양영희 (부산대학교 의과대학 정신과학교실) ;
  • 오승민 (서울대학교 의과대학 정신과학교실) ;
  • 홍순범 (서울대학교 의과대학 정신과학교실) ;
  • 박민현 (서울대학교 의과대학 정신과학교실) ;
  • 김붕년 (서울대학교 의과대학 정신과학교실) ;
  • 신민섭 (서울대학교 의과대학 정신과학교실) ;
  • 유희정 (서울대학교 의과대학 정신과학교실) ;
  • 조수철 (서울대학교 의과대학 정신과학교실)
  • Received : 2013.01.07
  • Accepted : 2013.03.05
  • Published : 2013.03.31
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Abstract

Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

Keywords

References

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