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http://dx.doi.org/10.5765/jkacap.2013.24.1.21

Regional Brain Perfusion before and after Treatment with Methylphenidate According to the MspI Polymorphism of the Alpha-2A Adrenergic Receptor Gene in Children with Attention-Deficit Hyperactivity Disorder  

Park, Subin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Bae, Jeong-Hoon (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Yang, Young-Hui (Department of Psychiatry, College of Medicine, Pusan National University)
Oh, Seungmin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Hong, Soon-Beom (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Park, Min-Heyon (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Kim, Boong-Nyun (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Yoo, Hee-Jeong (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine)
Publication Information
Journal of the Korean Academy of Child and Adolescent Psychiatry / v.24, no.1, 2013 , pp. 21-27 More about this Journal
Abstract
Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.
Keywords
Attention-Deficit Hyperactivity Disorder; ADRA2A; Single-Photon Emission Computed Tomography; Pharmacogenetics;
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