Bulletin of the Korean Chemical Society

  • 제32권9호
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  • Pages.3411-3420
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  • 2011
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Effect of Cationic and Anionic Porphyrins on the Structure and Activity of Adenosine Deaminase

  • 투고 : 2011.06.14
  • 심사 : 2011.07.29
  • 발행 : 2011.09.20
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초록

Kinetic and structural studies have been carried out on the effects of meso-tetrakis(4-sulfonatophenyl)-porphyrin ($H_2TPPS_4$) as an anionic and meso-tetrakis(3-N-methyl-pyridyl)porphyrin ($H_2TMPYP$) as a cationic porphyrin with adenosine deaminase (ADA) in 25 mM citrate/phosphate buffer, pH = 4-8, at $37^{\circ}C$ using UVvis spectrophotometry, circular dichroism (CD), fluorescence spectrophotometry as well as molecular dynamics (MD) and molecular docking. Kinetic results showed that the two porphyrins are non-competitive inhibitors. Increasing pH, increases $K_I$ and cationic porphyrin has a higher $K_I$ and lower binding constant ($K_b$) at all pH ranges. Analyzing the secondary structure revealed that both ligands decrease the secondary structure and that the anionic porphyrin is more effective.

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피인용 문헌

  1. Interaction of Cationic and Anionic Phthalocyanines with Adenosine Deaminase, Molecular Dynamics Simulation and Docking Studies vol.03, pp.04, 2013, https://doi.org/10.4236/cmb.2013.34010
  2. Absorbtion Spectroscopy, Molecular Dynamics Calculations, and Multivariate Curve Resolution on the Phthalocyanine Aggregation vol.35, pp.5, 2011, https://doi.org/10.5012/bkcs.2014.35.5.1440
  3. Comparative study of the interaction of meso-tetrakis (N-para-trimethyl-anilium) porphyrin (TMAP) in its free base and Fe derivative form with oligo(dA.dT)15and oligo(dG.dC)15 vol.33, pp.7, 2015, https://doi.org/10.1080/07391102.2014.963674