The Korean Journal of Pesticide Science (농약과학회지)

The Korean Society of Pesticide Science (한국농약과학회)
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Toxicity Assessment and Establishment Acceptable Daily Intake of Pyrimisulfan

피리미설판(Pyrimisulfan)의 독성평가와 일일섭취허용량 설정

  • Jeong, Mi-Hye (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Park, Kyung-Hun (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Park, Jae-Eup (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kwack, Seung-Jon (Department of Toxicological Evaluation and Research, National Institute of Food and Drug Evaluation, Korea Food and Drug Administration) ;
  • Kim, Young-Bum (Korea Institute of Toxicology) ;
  • Han, Bum-Seok (GLP center, Hoseo University) ;
  • Son, Woo-Chen (Asan Institute for Life Science, Asan Medical Center)
  • 정미혜 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박경훈 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 박재읍 (국립농업과학원 농산물안전성부 농자재평가과) ;
  • 곽승준 (식품의약품 안전평가원 독성평가연구부) ;
  • 김용범 (한국화학연구원 안정성평가연구소) ;
  • 한범석 (호서대학교 GLP센터) ;
  • 손우찬 (아산병원 아산생명과학연구소)
  • Received : 2011.02.10
  • Accepted : 2011.04.06
  • Published : 2011.06.30
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Abstract

Pyrimisulfan is a herbicide. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and also to determine its acceptable daily intake. Pyrimisulfan was excreted mostly by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic and chronic toxicity and carcinogenicity showed changes of hematology and liver.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Pyrimisulfan is 0.1 mg/kg/ bw/day, based on the NOAEL of 10 mg/kg/ bw/day of 90-days repeated dose oral toxicity study in dogs while applying an uncertainty factor of 100.

피리미설판에 대한 독성을 평가하고 일일섭취허용량을 설정하기 위하여 다양한 인축독성 시험성적서를 검토하였다. 대사시험결과, 주로 대변을 통해 배설되었으며, 급성독성은 낮았고, 피부, 안점막자극성과 피부감작성은 없었다. 랫드 90일 반복투여 경구독성시험결과에서 피리미설판 투여에 따른 영향은 혈액학적지표 및 간장에서 확인되었고 발암성은 없었으며, 번식독성, 기형독성 등에서 번식능력 몇 기형에 대한 영향 및 유전독성은 확인되지 않았다. 최대무작용량은 개 90일 반복투여 경구독성시험 10 mg/kg/day였으며, 안전계수 100으로 나눈 0.1 mg/kg/day을 일일섭취허용량(ADI)으로 설정하였다.

Keywords

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