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Toxicity Assessment and Establishment Acceptable Daily Intake of Pyrimisulfan  

Jeong, Mi-Hye (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration)
Park, Kyung-Hun (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration)
Park, Jae-Eup (Agro-Material Safety Evaluating Division, Department of Agro-Food Safety, National Academy of Agricultural Science, Rural Development Administration)
Kwack, Seung-Jon (Department of Toxicological Evaluation and Research, National Institute of Food and Drug Evaluation, Korea Food and Drug Administration)
Kim, Young-Bum (Korea Institute of Toxicology)
Han, Bum-Seok (GLP center, Hoseo University)
Son, Woo-Chen (Asan Institute for Life Science, Asan Medical Center)
Publication Information
The Korean Journal of Pesticide Science / v.15, no.2, 2011 , pp. 208-217 More about this Journal
Abstract
Pyrimisulfan is a herbicide. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and also to determine its acceptable daily intake. Pyrimisulfan was excreted mostly by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic and chronic toxicity and carcinogenicity showed changes of hematology and liver.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Pyrimisulfan is 0.1 mg/kg/ bw/day, based on the NOAEL of 10 mg/kg/ bw/day of 90-days repeated dose oral toxicity study in dogs while applying an uncertainty factor of 100.
Keywords
ADI; Herbicide; NOAEL; Pesticide; Pyrimisulfan;
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