Anti-Wrinkle Effect of Ulmus davidiana Extracts

유근피 추출물의 피부개선효과

  • Kim, Young-Ock (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Seo, Yong-Chang (Medical & Bio-Material Research Center, Kangwon National University) ;
  • Lee, Hyeon-Yong (Medical & Bio-Material Research Center, Kangwon National University) ;
  • Oh, Sook-Myung (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee, Sang-Won (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kim, Hyung-Don (Department of Herbal Crop Research, NIHHS, RDA)
  • 김영옥 (국립원예특작과학원 인삼특작부) ;
  • 서용창 (강원대학교 의료.바이오신소재융복합연구센터) ;
  • 이현용 (강원대학교 의료.바이오신소재융복합연구센터) ;
  • 오명숙 (경희대학교 약학대학 한약학과) ;
  • 이상원 (국립원예특작과학원 인삼특작부) ;
  • 김형돈 (국립원예특작과학원 인삼특작부)
  • Received : 2011.12.15
  • Accepted : 2011.12.23
  • Published : 2011.12.30


The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly shows antioxidant, anticancer, and anti-inflammatory effects. In this study, we investigated the protective effects of Ulmus davidiana var. japonica ethanolic extract (UDE) on UVB irradiation-induced wrinkle in hairless mice. We evaluated for their free radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the anti-elastase activities, and for their anti-matrix metalloproteinase-1 (MMP-1) activity in human skin fibroblast cells. In the wrinkle measurement and image analysis of skin replicas, the results showed that UDE significantly inhibited wrinkle formation caused by chronic UVB irradiation. These results suggest that UDE has anti-wrinkle activity.



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