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http://dx.doi.org/10.7783/KJMCS.2011.19.6.508

Anti-Wrinkle Effect of Ulmus davidiana Extracts  

Kim, Young-Ock (Department of Herbal Crop Research, NIHHS, RDA)
Seo, Yong-Chang (Medical & Bio-Material Research Center, Kangwon National University)
Lee, Hyeon-Yong (Medical & Bio-Material Research Center, Kangwon National University)
Oh, Sook-Myung (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University)
Lee, Sang-Won (Department of Herbal Crop Research, NIHHS, RDA)
Kim, Hyung-Don (Department of Herbal Crop Research, NIHHS, RDA)
Publication Information
Korean Journal of Medicinal Crop Science / v.19, no.6, 2011 , pp. 508-513 More about this Journal
Abstract
The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly shows antioxidant, anticancer, and anti-inflammatory effects. In this study, we investigated the protective effects of Ulmus davidiana var. japonica ethanolic extract (UDE) on UVB irradiation-induced wrinkle in hairless mice. We evaluated for their free radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the anti-elastase activities, and for their anti-matrix metalloproteinase-1 (MMP-1) activity in human skin fibroblast cells. In the wrinkle measurement and image analysis of skin replicas, the results showed that UDE significantly inhibited wrinkle formation caused by chronic UVB irradiation. These results suggest that UDE has anti-wrinkle activity.
Keywords
Anti-Wrinkle; Ulmus davidiana; UVB; DPPH; MMP-1;
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Times Cited By KSCI : 4  (Citation Analysis)
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