Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Suppressive effect of electrolyzed reduced water on the paraben-induced DNA damage in human dermal fibroblast cells

파라벤에 의한 피부섬유아세포의 DNA 손상과 환원전리수의 억제 효과

  • Yu, A-Reum (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Ryoo, Kun-Kul (Department of Display Materials Engineering, Soonchunhyang University) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
  • 유아름 (순천향대학교 의료생명공학과) ;
  • 류근걸 (순천향대학교 디스플레이신소재공학과) ;
  • 이미영 (순천향대학교 의료생명공학과)
  • Received : 2010.10.05
  • Accepted : 2010.11.19
  • Published : 2010.11.30
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Abstract

Parabens have been widely used as preservatives in cosmetics due to the presumed low toxicity and long history of safe use. However, recent studies have shown the potent toxicity of parabens. In order to know if electrolyzed reduced water could suppress the oxidative DNA damage of HDF cell by methylparaben, one of the frequently used parabens, we performed comet assay in this study. As a result, interestingly, electrolyzed reduced water could suppress methylparaben-induced oxidative DNA damage in HDF cells.

파라벤은 낮은 독성과 안전성으로 인해 화장품 보존제로 널리 사용되어 왔다. 그러나 최근 파라벤의 잠재적 독성이 알려지고 있다. 본 연구에서는 환원전리수가 널리 사용되는 메틸파라벤에 의한 사람 피부섬유아 세포의 DNA 산화손상을 억제할 수 있는지 알아보기 위하여 코멧어세이를 실시하였다. 그 결과 흥미롭게도 환원전리수는 파라벤에 의한 피부섬유아세포 DNA의 산화손상을 억제할 수 있었다.

Keywords

References

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