Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats

  • Zhao, Zheng Lin (Department of Biochemistry, Mudanjiang Medical University) ;
  • Zhao, Guang Wen (Department of General Surgery, Yanbian Medical College, Yanbian University) ;
  • Li, Li (Department of Pharmacology, Mudanjiang Medical University) ;
  • Li, Meng Quan (Department of Pharmacology, Mudanjiang Medical University) ;
  • Guan, Li Xin (Department of Pharmacology, Mudanjiang Medical University) ;
  • Yang, Xu Dong (Department of Pharmacology, Mudanjiang Medical University) ;
  • Li, Hou Zhong (Department of Pharmacology, Mudanjiang Medical University) ;
  • Lin, Feng (Department of Pharmacology, Mudanjiang Medical University) ;
  • Lee, Jong-Rok (The Research Center for Biomedical Resource of Oriental Medicine, Daegu Haany University) ;
  • Zhao, Rong Jie (Department of Pharmacology, Mudanjiang Medical University)
  • Published : 2009.03.01
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Abstract

The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.

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References

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