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http://dx.doi.org/10.5487/TR.2009.25.1.017

Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats  

Zhao, Zheng Lin (Department of Biochemistry, Mudanjiang Medical University)
Zhao, Guang Wen (Department of General Surgery, Yanbian Medical College, Yanbian University)
Li, Li (Department of Pharmacology, Mudanjiang Medical University)
Li, Meng Quan (Department of Pharmacology, Mudanjiang Medical University)
Guan, Li Xin (Department of Pharmacology, Mudanjiang Medical University)
Yang, Xu Dong (Department of Pharmacology, Mudanjiang Medical University)
Li, Hou Zhong (Department of Pharmacology, Mudanjiang Medical University)
Lin, Feng (Department of Pharmacology, Mudanjiang Medical University)
Lee, Jong-Rok (The Research Center for Biomedical Resource of Oriental Medicine, Daegu Haany University)
Zhao, Rong Jie (Department of Pharmacology, Mudanjiang Medical University)
Publication Information
Toxicological Research / v.25, no.1, 2009 , pp. 17-21 More about this Journal
Abstract
The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.
Keywords
Schizandra Chinensis Fruit; Cadmium; Monoamines; Brain; Rat;
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