Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-Platelet Aggregation Effect of Extract from Gamisopunghwalheol-tang in Vitro

가미소풍활혈탕의 혈소판 응집억제 작용에 대한 in vitro 연구

  • Lee, Hae-Yong (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Min, Kyoung-Yoon (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Kim, Seul-Ji (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Park, Youn-Ju (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Yang, Ga-Eun (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Lee, Mi-Jung (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Lew, Jae-Whan (East West Integrated Medicine, Oriental Internal Medicine, Kyunghee Oriental Medicine Hospital of Kunghee University) ;
  • Lee, Beom-Joon (Department of Internal Medicine, Kangnam Korean Hospital, Kyunghee University) ;
  • Cho, In-Young (Graduate School of East-West Medical Science, Kyunghee University)
  • 이혜영 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 민경윤 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 김슬지 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 박영주 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 양가은 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 이미정 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 류재환 (경희대학교 부속 한방병원 내과학교실 동서협진실) ;
  • 이범준 (강남경희한방병원 내상성인병센터) ;
  • 조인영 (경희대학교 동서의학대학원)
  • Published : 2009.10.25
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Abstract

The study was designed to test anti-platelet effect and find out anti-platelet mechanism of extract from Gamisopunghwalheol-tang in vitro. The extract was investigated for the inhibition against the aggregation of human platelet suspensions induced from collagen by aggregometer. And also the extract was investigated for the inhibition against the aggregation of human platelet suspensions who is taking aspirin or clopidogrel induced from collagen by aggregometer. In collagen-induced platelet aggregation test, the extract significantly inhibited collagen-induced platelet aggregation in a concentration-dependent manner(p<0.05). The extract significantly inhibited collagen-induced platelet aggregation of human platelet who is taking aspirin or clopidogrel ing 0 mg/ml concentration(p<0.05). And the extract inhibited more ingpatients who is taking aspirin. These results show that the extract from Gamisopunghwalheol-tang has anti-platelet aggregation effect.

Keywords

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