생물정신의학 (Korean Journal of Biological Psychiatry)
- 제15권4호
- /
- Pages.288-296
- /
- 2008
- /
- 1225-8709(pISSN)
- /
- 2005-7571(eISSN)
한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구
No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients
- 장호준 (순천향대학교 의과대학 신경정신과학교실) ;
- 문현일 (순천향대학교 의과대학 신경정신과학교실) ;
- 이연정 (순천향대학교 의과대학 신경정신과학교실) ;
- 김임렬 (계요병원) ;
- 이인상 (진주정신병원) ;
- 서한길 (진주정신병원) ;
- 김기훈 (연세대학교 의공학과) ;
-
신태민
(연세대학교 의공학과) ;
-
박병래
((주)에스엔피 제네틱스) ;
-
신형두
((주)에스엔피 제네틱스) ;
- 한선호 (순천향대학교 의과대학 신경정신과학교실) ;
-
한상우
(순천향대학교 의과대학 신경정신과학교실) ;
-
우성일
(순천향대학교 의과대학 신경정신과학교실)
- Jang, Ho Joon (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
- Moon, Hyun-Il (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
- Lee, Yeon Jung (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
- Kim, Im-Yel (Keyo Hospital) ;
- Lee, In-Sang (Jinju Mental Hospital) ;
- Seo, Han-Gil (Jinju Mental Hospital) ;
- Kim, Ki-Hoon (Department of Biomedical Engineering, Yonsei University) ;
-
Shin, Tae-Min
(Department of Biomedical Engineering, Yonsei University) ;
-
Park, Byung-Lae
(SNP Genetics) ;
-
Shin, Hyung Doo
(SNP Genetics) ;
- Han, Sun Ho (Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
-
Han, Sang-Woo
(Department of Neuropsychiatry, College of Medicine, Soonchunhyang University) ;
-
Woo, Sung-Il
(Department of Neuropsychiatry, College of Medicine, Soonchunhyang University)
- 발행 : 2008.11.30
초록
Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was
키워드