Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Idiopathic Polymyositis in a Young Mature Alaskan malamute

젊은 성숙 알라스칸 말라뮤트에서 특발성 다발성근염 증례

  • Lee, Jae-Il (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University) ;
  • Hong, Sung-Hyeok (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University) ;
  • Son, Hwa-Young (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myung-Cheol (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University)
  • 이재일 (충남대학교 수의과대학 외과학교실) ;
  • 홍성혁 (충남대학교 수의과대학 외과학교실) ;
  • 손화영 (충남대학교 수의과대학 병리학교실) ;
  • 김명철 (충남대학교 수의과대학 외과학교실)
  • Published : 2007.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Clinical and histopathologic features of idopathic polymyositis in twenty-month-old Alaskan malamute dog are described. The clinical signs were progressive exercise intolerance with acute exacerbation of weakness, muscle atrophy, synchronous pelvic limb gait, short stiff steps and tip-toeing as like walking on eggshells. Physical and clinical examination revealed no evidence of neurologic, skeletal and secondary muscular disorders associated with other diseases. Therefore muscle biopsy was performed at the most severe muscle atrophy lesions to confirm by histopathology. Histopathologic findings documented mononuclear cell infiltration and necrosis of muscle fiber and it was diagnosed as idiopathic polymyositis. Initial treatment was focused on pain relief. Prednisone at immunosuppressive dose (2 mg/kg) was administered orally twice daily. After 3 weeks of starting treatment, the patient showed improvement of gait, appetite, exercise as well as gradually return to normal state of hematologic and serum chemistry profiles.

20 개월령의 알라스칸 말라뮤트 견에서 특발성 다발성근염의 임상증상과 병리학적 소견을 서술하였다. 임상 증상은 급성 허약을 동반한 진행성 운동불내성, 근 위축, 후지의 동시적 걸음걸이, 계란 위를 발끝으로 걷듯 짧고 경직된 걸음 등을 보였다. 신체검사와 임상검사에서는 신경계나 골격계 그리고 다른 질병과 관련된 이차적인 근 질환의 증거가 없었다. 그래서 가장 근 위축이 심한 부위에서 병리조직 검사를 위한 근 생검을 실시하였다. 골격근의 병리검사 결과 근 섬유의 괴사와 함께 단핵세포의 침윤이 관찰되어, 특발성 다발성근염으로 진단하였다. 초기치료는 통증경감과 보조치료를 시작하여 프레드니손 2 mg/kg를 경구로 매일 투여하는 면역억제 요법을 시행하였다. 3주 후 환자는 혈액, 혈청학적 검사에서 정상으로 회복될 뿐만 아니라 걸음걸이, 식욕, 운동의 향상을 나타냈다.

Keywords

References

  1. Arahata K, Engel AG. Monoclonal antibody analysis of mono nuclear cells in myopathies. IV: Cell-mediated cytotoxicity and muscle fiber necrosis. Ann Neurol 1988; 23: 168-173 https://doi.org/10.1002/ana.410230210
  2. Averill DJ. Diseases of the muscle. Vet Clin North Am Small Anim Pract 1980; 10: 223-234 https://doi.org/10.1016/S0195-5616(80)50013-6
  3. Bartoccioni E. MHC class , MHC class and intercellular adhesion molecule-l (ICAM-I) expression in inflammatory myopathies. Clin Exp Immunol 1994; 95: 166-172 https://doi.org/10.1111/j.1365-2249.1994.tb06032.x
  4. Duncan ID, Griffith IR. Inflammaoty muscle disease in the dog. CUIT Vet Ther 1983; 8: 779-782
  5. Engel AG, Arahata K. Monoclonal antibody analysis of mononuclear cells in myopathies.: Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 1984; 16: 209-215 https://doi.org/10.1002/ana.410160207
  6. Fambacch GC. Myositis in the dog. Comp Contin Educ Pract Vet 1979; 1: 183-188
  7. Kornegay JN, Gorgacz EJ, Dawe DL, Bowen JM, White NA, DeBuysscher EV. Polymyositis in dog. J Am Vet Med Assoc 1980; 176: 431-438
  8. Lindberg G, Oldfors A, Tarkowski A. Local T-cell proliferation and differentiation in inflammatory myopathies. Scand J Immunol 1995; 41: 421-426 https://doi.org/10.1111/j.1365-3083.1995.tb03587.x
  9. Mantegazza R, Adreetta F, Bernasconi P. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. J Clin Invest 1993; 91: 2880-2886 https://doi.org/10.1172/JCI116533
  10. Morita T, Shimada A, Yashiro S, Takeuchi T, Hikasa Y, Okamoto Y, Mabuchi Y. Myofiber expression of class I major histocompatibility complex' accompanied by CD8+ Tcell- associated myofiber injury in a case of canine polymyositis. Vet Pathol. 2002; 39: 512-515 https://doi.org/10.1354/vp.39-4-512
  11. Morozumi M, Oyama Y, Kurosu Y, Nakayama H, Goto N, Yasuda K, Sasaki N, Tokuriki M. Immune-mediated polymyositis in a dog. J Vet Med Sci. 1991; 53: 511-512 https://doi.org/10.1292/jvms.53.511
  12. Neumann J, Bilzer T. Evidence for MHC-1-restricted CD8+ T-cell-mediated immunopathology in canine masticatory muscle myositis and polymyositis. Muscle Nerve. 2006; 33: 215-224 https://doi.org/10.1002/mus.20456
  13. Orvis JS, Cardinet GH. Canine muscle fiber types and susceptibility of masticatory muscles to myositis. Muscle Nerve 1981; 4: 354-359 https://doi.org/10.1002/mus.880040411
  14. Podell M. Inflammatory Myopathies. Vet Clin North Am Small Anim Pract 2002; 32(1): 147-167 https://doi.org/10.1016/S0195-5616(03)00083-4
  15. Poncelet L, Fontaine M, Balligand M. Polymyositis associated with Leptospira australis infection in a dog. Vet Rec. 1991 ; 13: 40
  16. Shelton GD, Bandmann E. Electrophoretic comparison of myosins from masticatory muscles and selected limb muscles in the dog. Am J Vet Res 1985; 46: 493-498
  17. Shelton GD, Cardinet GH. Canine masticatory muscle disorders. Curr Vet Ther 1989; 10: 816-819