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Idiopathic Polymyositis in a Young Mature Alaskan malamute  

Lee, Jae-Il (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University)
Hong, Sung-Hyeok (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University)
Son, Hwa-Young (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University)
Kim, Myung-Cheol (Laboratory of Veterinary Surgery College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.24, no.2, 2007 , pp. 244-246 More about this Journal
Abstract
Clinical and histopathologic features of idopathic polymyositis in twenty-month-old Alaskan malamute dog are described. The clinical signs were progressive exercise intolerance with acute exacerbation of weakness, muscle atrophy, synchronous pelvic limb gait, short stiff steps and tip-toeing as like walking on eggshells. Physical and clinical examination revealed no evidence of neurologic, skeletal and secondary muscular disorders associated with other diseases. Therefore muscle biopsy was performed at the most severe muscle atrophy lesions to confirm by histopathology. Histopathologic findings documented mononuclear cell infiltration and necrosis of muscle fiber and it was diagnosed as idiopathic polymyositis. Initial treatment was focused on pain relief. Prednisone at immunosuppressive dose (2 mg/kg) was administered orally twice daily. After 3 weeks of starting treatment, the patient showed improvement of gait, appetite, exercise as well as gradually return to normal state of hematologic and serum chemistry profiles.
Keywords
idiopathic; polymyositis; stiff; immunosuppression; Alaskan malamute;
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