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Effects of Proton on Lysolipid-induced Actions in OGR1-subfamily GPCRs

  • Lim, Sung-Mee (Department of Food Science & Technology, Tongmyong University) ;
  • Im, Dong-Soon (Laboratory of Pharmacology, College of Pharmacy (BK2l Project) and Research Institute of Drug Development, Pusan National University)
  • Published : 2007.03.30

Abstract

Lysolipids such as lysophosphatidylcholine (LPC), sphingosylphosphorylcholine (S PC), galactosylsphingosine (psychosine) have been matched as ligands for OGR1-subfamily G-protein-coupled receptors (GPCR), consisted of OGR1, GPR4, G2A, and TDAG8. Recently, those members of GPCRS have been reported as proton-sensing GPCRs. We used Jurkat T cells, which express four members of OGR1 subfamily GPCRs endogenously to investigate effects of proton on lysolipid-induced several cellular events. We found no significant effect of proton on the lysolipid-induced $Ca^{2+}$ increase and ROS production in Jurkat T cells. Further investigation is necessary to clarify the relationship of lysolipid and proton on the OGR1-subfamily GPCRs.

Keywords

References

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