Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Proton on Lysolipid-induced Actions in OGR1-subfamily GPCRs

  • Lim, Sung-Mee (Department of Food Science & Technology, Tongmyong University) ;
  • Im, Dong-Soon (Laboratory of Pharmacology, College of Pharmacy (BK2l Project) and Research Institute of Drug Development, Pusan National University)
  • Published : 2007.03.30
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Abstract

Lysolipids such as lysophosphatidylcholine (LPC), sphingosylphosphorylcholine (S PC), galactosylsphingosine (psychosine) have been matched as ligands for OGR1-subfamily G-protein-coupled receptors (GPCR), consisted of OGR1, GPR4, G2A, and TDAG8. Recently, those members of GPCRS have been reported as proton-sensing GPCRs. We used Jurkat T cells, which express four members of OGR1 subfamily GPCRs endogenously to investigate effects of proton on lysolipid-induced several cellular events. We found no significant effect of proton on the lysolipid-induced $Ca^{2+}$ increase and ROS production in Jurkat T cells. Further investigation is necessary to clarify the relationship of lysolipid and proton on the OGR1-subfamily GPCRs.

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References

  1. Chang YJ, Lee YK, Lee EH, Park JJ, Chung SK and Im DS. Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and $Ca^{2+}$ in the U937 monocyte cell line. Arch Pharm Res 29, 657-665, 2006 https://doi.org/10.1007/BF02968250
  2. Dandona P, Thusu K, Cook S, Snyder B, Makowski J, Armstrong D and Nicotera T. Oxidative damage to DNA in diabetes mellitus. Lancet 347, 444-445, 1996 https://doi.org/10.1016/S0140-6736(96)90013-6
  3. Dobmeyer TS, Findhammer S, Dobmeyer JM, Klein SA, Raffel B, Hoelzer D, Helm EB, Kabelitz D and Rossol R. Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: role for lymphocyte loss in HIV infection. Free Radic Biol Med 22, 775-785, 1997 https://doi.org/10.1016/S0891-5849(96)00403-0
  4. Finkel T. Redox-dependent signal transduction. FEBS Lett 476, 52-54, 2000 https://doi.org/10.1016/S0014-5793(00)01669-0
  5. Fredriksson R, Lagerstrom MC, Lundin LG and Schioth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63, 1256-1272, 2003 https://doi.org/10.1124/mol.63.6.1256
  6. Frenkel K, Khasak D, Karkoszka J, Shupack J and Stiller M. Enhanced antibody titers to an oxidized DNA base in inflammatory and neoplastic diseases. Exp Dermatol 1, 242-247, 1992 https://doi.org/10.1111/j.1600-0625.1992.tb00083.x
  7. Himmel HM, Meyer zu Heringdorf D, Windorfer B, van Koppen CJ, Ravens U and Jakobs KH. Guanine nucleotide-sensitive inhibition of L-type $Ca^{2+}$ current by lysosphingolipids in RINm5F insulinoma cells. Mol Pharmacol 53, 862-869, 1998
  8. Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K and Arioka M. Secretory phospholipase $A_{2}$ induces neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. J Biol Chem 280, 28044-28052, 2005 https://doi.org/10.1074/jbc.M503343200
  9. Im DS. Orphan G protein-coupled receptors and beyond. Jpn J Pharmacol 90, 101-106, 2002 https://doi.org/10.1254/jjp.90.101
  10. Im DS. Discovery of new G protein-coupled receptors for lipid mediators. J Lipid Res 45, 410-418, 2004 https://doi.org/10.1194/jlr.R300006-JLR200
  11. Im DS. Two ligands for a GPCR, proton vs lysolipid. Acta Pharmacol Sin 26: 1435-1441, 2005 https://doi.org/10.1111/j.1745-7254.2005.00237.x
  12. Im DS, Heise CE, Nguyen T, O'Dowd BF and Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. J Cell Biol 153, 429-434, 2001 https://doi.org/10.1083/jcb.153.2.429
  13. Im YJ, Lee YK, Chung HY and Im DS. Multiple actions of lysophosphatidylcholine in human Jurkat T cells. Acta Pharmacol Sin 27, 700-707, 2006 https://doi.org/10.1111/j.1745-7254.2006.00339.x
  14. Ishii S, Kihara Y and Shimizu T. Identification of T cell deathassociated gene 8 (TDAG8) as a novel acid sensing G-proteincoupled receptor. J Biol Chem 280, 9083-9087, 2005 https://doi.org/10.1074/jbc.M407832200
  15. Jatana M, Giri S and Singh AK. Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine. Neurosci Lett 330, 183-187, 2002 https://doi.org/10.1016/S0304-3940(02)00655-9
  16. Kabarowski JH, Zhu K, Le LQ, Witte ON and Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science 293, 702-705, 2001 https://doi.org/10.1126/science.1061781
  17. Kim HS, Lee EH, Ko SR, Choi KJ, Park JH and Im DS. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27, 429-435, 2004 https://doi.org/10.1007/BF02980085
  18. Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL, Lum H, Anand-Apte B and Xu Y. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. Faseb J 19, 819-821, 2005 https://doi.org/10.1096/fj.04-2988fje
  19. Konikova E, Babusikova O, Kusenda J and Glasova M. Detection of cytoplasmic and surface membrane markers in cells of some human hematopoietic cell lines. Neoplasma 39, 337-342, 1992
  20. Larsson R and Cerutti P. Oxidants induce phosphorylation of ribosomal protein S6. J Biol Chem 263, 17452-17458, 1988
  21. Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF and Witte ON. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity 14, 561-571, 2001 https://doi.org/10.1016/S1074-7613(01)00145-5
  22. Lee EH, Lee YK, Im YJ, Kim JH, Okajima F and Im DS. Dimethylsphingosine regulates intracellular pH and $Ca^{2+}$ in human monocytes. J Pharmacol Sci 100, 289-296, 2006 https://doi.org/10.1254/jphs.FPJ05009X
  23. Legradi A, Chitu V, Szukacsov V, Fajka-Boja R, Szekely Szucs K and Monostori E. Lysophosphatidylcholine is a regulator of tyrosine kinase activity and intracellular $Ca^{2+}$ level in Jurkat T cell line. Immunol Lett 91, 17-21, 2004 https://doi.org/10.1016/j.imlet.2003.10.009
  24. Lieber MR. Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system. Am J Pathol 153, 1323-1332, 1998 https://doi.org/10.1016/S0002-9440(10)65716-1
  25. Lipskaia L and Lompre AM. Alteration in temporal kinetics of $Ca^{2+}$ signaling and control of growth and proliferation. Biol Cell 96, 55-68, 2004 https://doi.org/10.1016/j.biolcel.2003.11.001
  26. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM and Seuwen K. Proton-sensing Gprotein-coupled receptors. Nature 425, 93-98, 2003 https://doi.org/10.1038/nature01905
  27. McAllister-Sistilli CG, Caggiula AR, Knopf S, Rose CA, Miller AL and Donny EC. The effects of nicotine on the immune system. Psychoneuroendocrinology 23, 175-187, 1998 https://doi.org/10.1016/S0306-4530(97)00080-2
  28. Mogi C, Tomura H, Tobo M, Wang JQ, Damirin A, Kon J, Komachi M, Hashimoto K, Sato K and Okajima F. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. J Pharmacol Sci 99, 160-167, 2005 https://doi.org/10.1254/jphs.FP0050599
  29. Moolenaar WH. Bioactive lysophospholipids and their G proteincoupled receptors. Exp Cell Res 253, 230-238, 1999 https://doi.org/10.1006/excr.1999.4702
  30. Murakami N, Yokomizo T, Okuno T and Shimizu T. G2A is a proton-sensing G-protein coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 279, 42484-42491, 2004 https://doi.org/10.1074/jbc.M406561200
  31. Perez DM. From Plants to Man: The GPCR 'Tree of Life'. Mol Pharmacol 67, 1383-1384, 2005 https://doi.org/10.1124/mol.105.011890
  32. Radu CG, Nijagal A, McLaughlin J, Wang L and Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A 102, 1632-1637, 2005 https://doi.org/10.1073/pnas.0409415102
  33. Schreck R, Rieber P and Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Embo J 10, 2247-2258, 1991
  34. Spiegel S and Milstien S. Sphingolipid metabolites: members of a new class of lipid second messengers. J Membr Biol 146, 225-237, 1995
  35. Sueyoshi N, Maehara T and Ito M. Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. J Lipid Res 42, 1197-1202, 2001
  36. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE and Gaitanaris GA. The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A 100, 4903-4908, 2003 https://doi.org/10.1073/pnas.0230374100
  37. Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Wakamatsu K, Koizumi H, Uede T, Tsujimoto G, Kurose H, Sato T, Harada A, Misawa N, Tomura H and Okajima F. TDAG8 is a protonsensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem 279, 45626-45633, 2004 https://doi.org/10.1074/jbc.M406966200
  38. Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y and Damron DS. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol 2, 261-267, 2000 https://doi.org/10.1038/35010529
  39. Yan JJ, Jung JS, Lee JE, Lee J, Huh SO, Kim HS, Jung KC, Cho JY, Nam JS, Suh HW, Kim YH and Song DK. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med 10, 161-167, 2004 https://doi.org/10.1038/nm989
  40. Zaka M and Wenger DA. Psychosine-induced apoptosis in a mouse oligodendrocyte progenitor cell line is mediated by caspase activation. Neurosci Lett 358, 205-209, 2004 https://doi.org/10.1016/j.neulet.2003.12.126
  41. Zhu K, Baudhuin LM, Hong G, Williams FS, Cristina KL, Kabarowski JH, Witte ON and Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. J Biol Chem 276, 41325-41335, 2001 https://doi.org/10.1074/jbc.M008057200