Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

in vitro Cytotoxic Effects of Wine Produced by Phellinus linteus Fermentation

상황버섯 균사체 발효주의 세포독성 비교

  • Choi Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Park Cheol (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Jung Il Hong (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Choi Byung Tae (Department of Anatomy Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Lee Yong Tae (Department of Physiology, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Park Dong Il (Department of Internal Medicine, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine) ;
  • Jeong Young-Kee (Department of Microbiology, College of Natural Sciences, Dongeui University)
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 박철 (동의대학교 한의과대학 생화학교실) ;
  • 정일홍 (동의대학교 한의과대학 생화학교실) ;
  • 최병태 (동의대학교 한의과대학 해부학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 박동일 (동의대학교 한의과대학 폐계내과학교실 및 한방바이오연구센터) ;
  • 정영기 (동의대학교 자연과학대학 미생물학과)
  • Published : 2005.08.01
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Abstract

Phellinus linteus (Berk. & M.A. Curtis) Teng, commonly referred to as Sangwhang in Korea, is a well-known species of the genus Phellinus, which attracts great attention due to its phamarcological values. P. linteus has been reported to produce anti-tumor, anti-angiogenic, anti-mutagenic and immunomodulatory activities in vivo and in vitro. However, despite extensive biochemical studies on P. linteus, the wine produced by P. linteus fermentation (WPLF) has poorly investigated. In the present study, it was compared the in vitro cytotoxic effects of WPLF with ethanol as positive control. WPLF as well as ethanol induced the inhibition of cell proliferation and morphological changes in both HepG2 and A549 cells in a concentration-dependent manner, however, WPLG treatment has less cytotoxic effects than ethanol treatment. These cytotoxic effects were associated with the induction of apoptotic cell death, but, WPLG treatment has less apoptotisis inducing effects than ethanol treatment.

Keywords

References

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