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in vitro Cytotoxic Effects of Wine Produced by Phellinus linteus Fermentation  

Choi Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Park Cheol (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Jung Il Hong (Department of Biochemistry, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Choi Byung Tae (Department of Anatomy Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Lee Yong Tae (Department of Physiology, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Park Dong Il (Department of Internal Medicine, Dongeui University College of Oriental Medicine and Biomedical Research Institute of Oriental Medicine)
Jeong Young-Kee (Department of Microbiology, College of Natural Sciences, Dongeui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.4, 2005 , pp. 950-954 More about this Journal
Abstract
Phellinus linteus (Berk. & M.A. Curtis) Teng, commonly referred to as Sangwhang in Korea, is a well-known species of the genus Phellinus, which attracts great attention due to its phamarcological values. P. linteus has been reported to produce anti-tumor, anti-angiogenic, anti-mutagenic and immunomodulatory activities in vivo and in vitro. However, despite extensive biochemical studies on P. linteus, the wine produced by P. linteus fermentation (WPLF) has poorly investigated. In the present study, it was compared the in vitro cytotoxic effects of WPLF with ethanol as positive control. WPLF as well as ethanol induced the inhibition of cell proliferation and morphological changes in both HepG2 and A549 cells in a concentration-dependent manner, however, WPLG treatment has less cytotoxic effects than ethanol treatment. These cytotoxic effects were associated with the induction of apoptotic cell death, but, WPLG treatment has less apoptotisis inducing effects than ethanol treatment.
Keywords
Phellinus linteus; fermented wine; cytotoxicity; apoptosis;
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