Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Antitrichomonas Activity of Herb-medicine Generally Used in Dong-Eui-Bo-Kham

동의보감의 한약재에 대한 항질편모충 효능에 대한 연구

  • Park, Chung-Un (Department of the Third Medicine, Professional Graduate School of Oriental Medicine, WonKwang University) ;
  • Lee, Geon-Mok (Department of the Third Medicine, Professional Graduate School of Oriental Medicine, WonKwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Ryu, Jae-Sook (Department of Parasitology, College of Medicine, Hanyang University) ;
  • Kim, Tae-Kyun (Department of Orthopedic Surgery, College of Medicine, Wonkwang University) ;
  • Kim, Jong-Ho (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Kim, Min-Kyeoung (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Song, Ho-Cheol (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University) ;
  • Park, Hyun (Department of Infection Biology, College of Medicine, Wonkwang University)
  • 박정운 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이건목 (원광대학교 한의학전문대학원 제3의학과) ;
  • 김윤철 (원광대학교 약학대학) ;
  • 류재숙 (한양대학교 의과대학 기생충학교실) ;
  • 김태균 (원광대학교 의과대학 정형외과학교실) ;
  • 김종호 (원광대학교 의과대학 감염생물학교실) ;
  • 김민경 (원광대학교 의과대학 감염생물학교실) ;
  • 송호철 (경희대학교 동서의학대학원) ;
  • 박현 (원광대학교 의과대학 감염생물학교실)
  • Published : 2005.02.25
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Abstract

Eighteen aqueous and two ethanol extracts of herb-medicine used for trichomoniasis therapies in Korea were assessed for their antitrichomonas activities. Two extracts(Sophorae radix, Phellodendri cortex) showed evident antitrichomonas activity at $8mg/m{\ell}$. Two mixture of Sophorae radix and Phellodendri cortex showed low antitrichomonas activity at 15mg/ml. Ethylacetate fraction of Sophorae radix showed the antitrichomonas activity of 400 mg/ml. This indicated that Sophorae radix is potent for a new effective and safe antitrichomonas agent.

Keywords

References

  1. Faure M, Drapier-Faure E. Vulvovaginitis. Rev Prat. 47(15): 1655-1660, 1997.
  2. Ferris DG, Hendrich J, Payne PM et al. Office laboratory diagnosis of vaginitis. Clinician-performed tests compared with rapid nucleic acid hybridization test. Fam Prac 41(6):575-581, 1995.
  3. Moldwin RM. Sexually transmitted protozoal infections. Trichomonas vaginalis, Entamoeba histolytica, and Giardia Lamblia. Urologic Clinics of North America 19(1): 93-101, 1992.
  4. Reitz M, Rumpf M, Knitza R. DNA single strand-breaks in lymphocytes after metronidazole therapy. Arzneimittelforschtmg 41(2): 155-156, 1991.
  5. Cavaliere A, Bacci M, Amorosi A et al. Induction of lung tumors and lymphomas in BALB/c mice by metronidazole. Tumori. 69(5): 379-382, 1983.
  6. Dunne RL, Dunn LA, Upcroft P, O'Donoghue PJ, Upcroft JA. Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis. Cell Res. Aug;13(4): 239-49, 2003.
  7. 許浚. 東醫寶鑑. 서울 대성문화사. 1992.
  8. Ryu JS, Choi HK, Min DY, Ha SE, Ahn MH, Effect of iron on the virulence of Trichomonas vaginalis. J Parasitol. Apr;87(2): 457-460, 2001.
  9. Josef G. Meingassner, Josefine Thurner. Strain of Trichomonas vaginalis Resisitant to Metronidazole and Other 5-Nitroimidazoles, 15(2): 254-257, 1979.
  10. 부인과학 교재편집위원회. 韓醫婦人科學(上). 서울. 정담출판사. 259, 263-265, 2001.
  11. Bracco PL, Bracco GL, Vassallo AM (1992) Benzidiamine in the tropical treatment of vaginitis caused by Gardnerella vaginalis. Minerva Glinecol 44(11): 573-584, 1992.
  12. Ison Ca, Taylor RFH, Link C et al. (1987) Lacal treatment for bacterial vaginosis. Br Med J 295: 886, 1987.
  13. Neri A, Rabinerson D, Kaplan B. Bacterial vaginosis. Obstet Gynecol Surv. 49(12): 809-813, 1994. https://doi.org/10.1097/00006254-199412000-00003
  14. Macickova T, Kettner M, Benes L The effect of nitrofuran and asymmetrically substituted urea on Trichomonas vaginalis and Tritrichomonas foetus in vitro and in vivo. Bratisl Lek Listy 91(1): 30-37, 1990.
  15. D'Auria FD, Simonetti G, Strippoli V Antimicrobial characteristics of a tincture of dequalinium chloride. Ann Ig 1(5): 1227-1241, 1989.
  16. Goldstein BP, King A, Ripamonti F et al. In-vitro activity of purpuromycin and MDL 63,604 against microorganisms that cause vaginitis and vaginosis. J Antimicrob Chemother 36(6): 1061-1065, 1995. https://doi.org/10.1093/jac/36.6.1061
  17. DeBouchet L, Spence MR, Rein MF et al. Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacine hydrochloride, and allation in the treatment of symptomatic trichomoniasis. Sex Transm Dis 24(3): 156-160, 1997. https://doi.org/10.1097/00007435-199703000-00006
  18. Escario JA, Igea AM, Contreras M et al. Antiparasitic activity of nine pyrazole derivatives against Trichomonas vaginalis, Entamoeba invadens and Plasmodium berghei. Ann Trop Med Parasitol 82(3): 257-262, 1988.
  19. Ryu. JS, Min DY, Kim MC, Kim NS, Shin MH . In Vitro Activities of 2,2'-Dipyridyl Against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis. J. Microbiol. Biotechnol. 11(1): 124-130, 2001.
  20. 김창민, 신민교, 이경순, 안덕균. 중약대사전. 도서출판 정담. 4101-4105, 341-346, 4509-4516, 1998.