생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

에탄올 투여로 유도한 생쥐의 인지기능 손상에 대한 길경 추출물의 개선효능

Ameliorating Effect of the Root Extract from Platycodon grandiflorum on the Ethanol-induced Cognitive Impairment in Mice

  • Kim, Young-Sup (Korea Research Institute of Chemical Technology) ;
  • Kim, Jung-Sook (Korea Research Institute of Chemical Technology) ;
  • Choi, Yeon-Hee (Korea Research Institute of Chemical Technology) ;
  • Seo, Jee-Hee (Korea Research Institute of Chemical Technology) ;
  • Lee, Jung-Won (Korea Research Institute of Chemical Technology) ;
  • Kim, Seong-Kie (Korea Research Institute of Chemical Technology) ;
  • Kang, Jong-Seong (College of Pharmacy, Chungnam National University) ;
  • Lee, Hyun-Sun (Korea Research Institute of Bioscience & Biotechnology) ;
  • Cho, Young-Soo (JangSaeng Doraji Research Institute of Biotechnology, JangSaeng Doraji Co. Ltd.) ;
  • Roh, Seong-Hwan (JangSaeng Doraji Research Institute of Biotechnology, JangSaeng Doraji Co. Ltd.) ;
  • Jeong, Young-Chul (Division of Food Science, Jinju International University) ;
  • Shim, Ki-Hwan (Division of Applied Life Science, Gyeongsang National University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
  • 발행 : 2004.09.30
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초록

The ameliorating effect of the MeOH extract of the root of Platycodon grandiflorum on the ethanol-induced cognitive dysfunction in mice was investigated. The total MeOH extract was devided into two fractions, saponin rich fraction and non-saponin fraction. The mice with repeated administration of the total MeOH extract and those with saponin rich fraction both showed a markedly prolongεd latency time upon the step-through test (passive avoidance performance) performed after acute ethanol intoxication, while those with non-saponin rich fraction did not. The results suggest that the extracts from the root of Platycodon grandiflorum exert a beneficial effect on ethanol-induced memory impairment in mice and also suggest that these effects of the extracts might be ascribed to the saponin constituents.

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참고문헌

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